Evidence map›Paper›PMID 39992778›Full record

Trial reportHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2025

Effectiveness of the smart program: Stepped-care HIV prevention for gay and bisexual adolescent boys.

Brian Mustanski, Kathryn Macapagal, Dennis H Li, Carlos E Rodriguez-Diaz, Rana Saber, Maggie Matson, David A Moskowitz, H Jonathon Rendina, Eric Laber, Daniel T Ryan and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brian MustanskiInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.ORCID 0000-0001-9222-5116
Kathryn MacapagalInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.
Dennis H LiInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.
Carlos E Rodriguez-DiazDepartment of Prevention and Community Health, George Washington University Milken Institute School of Public Health.
Rana SaberInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.
Maggie MatsonInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.
David A MoskowitzDepartment of Public Health Sciences, Biological Sciences Division, The University of Chicago.
H Jonathon RendinaDepartment of Epidemiology, George Washington University Milken Institute School of Public Health.
Eric LaberDepartment of Biostatistics & Bioinformatics, Duke University School of Medicine.
Daniel T RyanInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.
Michael E NewcombInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.

Funding

Virology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Michael E Newcomb · 2015 to 2026
$38.4M
A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSMU01MD011281 · NIMHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MUSTANSKI, BRIAN · 2016 to 2020
$9.7M
National Institutes of Health-funded Third Coast Center for AIDS ResearchNIAID NIH HHS P30 AI117943NIMHD NIH HHS U01 MD011281
6 · The paper itself

Abstract

objectiveAdolescent men who have sex with men (AMSM) have high HIV incidence and low rates of HIV testing and pre-exposure prophylaxis (PrEP) use. There are few evidence-based HIV prevention programs that meet the unique needs of AMSM. The sequential, multiple assignment, randomized trial (SMART) program is a stepped care package of increasingly intensive eHealth interventions that were developed specifically for English- and Spanish-speaking AMSM. The sequence included universal sexuality education (SMART Sex Ed), an automated motivation and behavioral skills focused intervention (SMART Squad), and motivational interviewing via videoconferencing (SMART Sessions).

methodThis SMART compared HIV testing, PrEP use, condomless anal sex (CAS), condom use intentions, and condom use self-efficacy outcomes for different embedded treatment sequences in the SMART program among a large sample of English- and Spanish-speaking AMSM (ages 13-18) in the U.S. states and territories (N = 1,306).

resultsIn most of the embedded treatment sequences, there were significant improvements across 12 months for most of the outcomes, including CAS with casual partners, HIV testing, PrEP use, and condom use self-efficacy. There were largely no changes in CAS inclusive of serious partnerships and condom use intentions declined in some regimes.

conclusionFindings from 12 months of follow-up provide evidence of the SMART program's long-term effectiveness, with particular benefits for the important outcomes of HIV testing and PrEP use. Given the lack of effective interventions for this high HIV-incidence population coupled with the potential for high reach given the eHealth modality, funders should put in place the resources to enable rapid implementation. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Indexed as

BisexualityHIV InfectionsHomosexuality, MaleMotivational InterviewingPre-Exposure ProphylaxisSexual and Gender MinoritiesAdolescentCondomsHumansMaleProgram EvaluationSelf EfficacySex EducationSexual BehaviorTelemedicine

Identifiers

PMID39992778
PMCPMC12392775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.