Evidence map›Paper›PMID 39992722›Full record

ReviewKidney3602025

Update on the Assessment of GFR in Patients with Cancer.

Verônica T Costa E Silva, Fei Xiong, Lea Mantz, Meghan E Sise, Sandra M Herrmann, Abhijat Kitchlu

Abstract readReview
In one paragraph

Review in Kidney360, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Modernizing renal eligibility in oncology trials.Lancet regional health. Americas · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Beyond Creatinine: A New Era of GFR Assessment in Patients with Cancer.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Verônica T Costa E SilvaServiço de Nefrologia, Faculdade de Medicina, Instituto do Câncer do Estado de São Paulo, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-8211-018
Fei XiongDivision of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0002-0966-5263
Lea MantzDepartment of Radiology, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0003-0998-8812
Meghan E SiseDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Sandra M HerrmannDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-3700-4537
Abhijat KitchluDivision of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4340-5046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate assessment of GFR is key in patients with cancer to guide drug eligibility, adjust dosing of systemic therapy, and minimize the risks of undertreatment and systemic toxicity. Several aspects of GFR evaluation in patients with cancer have been unclear, such as the choice of the GFR estimating equation and the overall lack of data on the reliability of new filtration markers, such as cystatin C. This uncertainty has led to concerns that inaccurate GFR estimation may have a large effect on clinical practice and research. Recent data have brought important developments to the field. The new and timely Kidney Disease Improving Global Outcomes 2024 Clinical Practice Guideline for the Evaluation and Management of CKD raised important considerations and provided guidance on key aspects of GFR evaluation in patients with cancer. The guidelines cover valid estimating equations, incorporation of cystatin C in GFR estimation, drawbacks of using race in GFR estimation, and acknowledge that non-GFR determinants of filtration markers may be prominent in patients with cancer, reducing the accuracy of GFR estimating equations, prompting greater utilization of GFR measurement. The aim of this review is to summarize advances in GFR evaluation in patients with cancer considering the new Kidney Disease Improving Global Outcomes guidelines and other recent data.

Indexed as

Glomerular Filtration RateNeoplasmsRenal Insufficiency, ChronicBiomarkersCystatin CHumansKidney Function TestsPractice Guidelines as TopicReproducibility of ResultsBiomarkersCystatin Ccancerchemotherapycisplatincisplatin nephrotoxicityCKDclinical trialcreatinine clearancedrug metabolismonco-nephrologyrenal function

Identifiers

PMID39992722
PMCPMC12136654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.