Evidence map›Paper›PMID 39992714›Full record

ArticleeLife2025

Chronic RNA G-quadruplex accumulation in aging and Alzheimer's disease.

Lena Kallweit, Eric Daniel Hamlett, Hannah Saternos, Anah Gilmore, Ann-Charlotte Granholm, Scott Horowitz

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. G-Quadruplexes Abet Neuronal Burnout in ALS and FTD.Antioxidants (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lena KallweitDepartment of Chemistry & Biochemistry and the Knoebel Institute for Healthy Aging, University of Denver, Denver, United States.ORCID https://orcid.org/0009-0007-2452-8300
Eric Daniel HamlettDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, United States.ORCID https://orcid.org/0000-0002-2900-7949
Hannah SaternosDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, United States.
Anah GilmoreDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, United States.
Ann-Charlotte GranholmDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID https://orcid.org/0000-0002-9685-7599
Scott HorowitzDepartment of Chemistry & Biochemistry and the Knoebel Institute for Healthy Aging, University of Denver, Denver, United States.ORCID https://orcid.org/0000-0002-1148-0105

Funding

Tau pathology in Down syndrome and Alzheimer'sRF1AG061566 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, MARGITTAI, MARTIN · 2019 to 2019
$3.4M
Exosome biology in Alzheimer's disease and concussion.R01AG071228 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, LEDREUX, AURELIE · 2021 to 2025
$3.1M
Nucleic Acids Roles in Protein Folding and AggregationR35GM142442 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI Scott Andrew Horowitz · 2021 to 2026
$2.4M
Noradrenergic dysfunction in Down SyndromeRF1AG070153 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI LEDREUX, AURÉLIE · 2020 to 2020
$1.8M
BrightFocus Foundation CA2018010Lejeune Foundation GRT-2023b/2277NIA NIH HHS 5R01AG071228-02NIA NIH HHS R01AG061566NIA NIH HHS R01AG070153NIA NIH HHS R01 AG071228NIA NIH HHS RF1 AG061566NIA NIH HHS RF1 AG070153NIGMS NIH HHS R35 GM142442NIGMS NIH HHS R35GM142442
6 · The paper itself

Abstract

As the world population ages, new molecular targets in aging and Alzheimer's disease (AD) are needed to combat the expected influx of new AD cases. Until now, the role of RNA structure in aging and neurodegeneration has largely remained unexplored. In this study, we examined human hippocampal

Indexed as

AgingAlzheimer DiseaseG-QuadruplexesHippocampusRNAAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeuronstau ProteinsRNAtau Proteinsagingalzheimer'sAPOEbiochemistrychemical biologyhumanneurosciencequadruplexRNATau

Identifiers

PMID39992714
PMCPMC11850002

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.