Evidence map›Paper›PMID 39992662›Full record

Observational studyTranslational vision science & technology2025

OCT Angiography of Type 1 Macular Neovascularization in AMD: A Morphometric Evaluation.

Maria Cristina Savastano, Claudia Fossataro, Matteo Mario Carlà, Valentina Cestrone, Ilaria Biagini, Clara Rizzo, Raphael Kilian, Sandrine A Zweifel, Daniel R Muth, Francesco Faraldi and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Cristina SavastanoOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Claudia FossataroOphthalmology Unit, Catholic University of the Sacred Heart, Rome, Italy.
Matteo Mario CarlàOphthalmology Unit, Catholic University of the Sacred Heart, Rome, Italy.
Valentina CestroneOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Ilaria BiaginiOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Clara RizzoOphthalmology Unit, University of Verona, Verona, Italy.
Raphael KilianOphthalmology Unit, University of Verona, Verona, Italy.
Sandrine A ZweifelDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Daniel R MuthDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Francesco FaraldiDepartment of Ophthalmology, Istituto Oftalmico di Torino, Torino, Italy.
Stanislao RizzoOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
David SarrafStein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To determine biomarkers of macular neovascularization (MNV) in neovascular age-related macular degeneration through the application of an automatic algorithm based optical coherence tomography angiography (OCTA) analysis. Methods: In this retrospective, observational, single-center, cross-sectional study, patients with a diagnosis of age-related macular degeneration complicated by type 1 MNV were included. MNV was detected with OCTA and scans were analyzed with a qualitative and quantitative open-source image processing package. For each analyzed image, we automatically acquired the following data: Total MNV area, vessel area, vessel density (VD), total number of branches, total number of vascular junctions, mean vessel length, mean vessel diameter, fractal dimension (FD), junction density, and vessel tortuosity. Results: The following morphological parameters revealed a significant negative correlation with best-corrected visual acuity: MNV area - Spearman ρ = -0.309 (P = 0.002); vessel area - Spearman ρ = -0.315 (P = 0.002); total number of vascular junctions - Spearman ρ = -0.285 (P = 0.005), and VL - Spearman ρ = -0.304 (P = 0.003). Immature MNV lesions were significantly associated with better vessel area than mature and hypermature lesions. Conclusions: Several automated MNV-associated morphological parameters can correlate with the best-corrected visual acuity. Further studies are warranted to determine if these OCTA biomarkers can be applied to guide anti-vascular endothelial growth factor therapy and predict response to treatment. Translational Relevance: The analysis of MNV biomarkers may have prognostic value in terms of visual function.

Indexed as

Choroidal NeovascularizationFluorescein AngiographyMacular DegenerationTomography, Optical CoherenceWet Macular DegenerationAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMacula LuteaMaleMiddle AgedRetinal VesselsRetrospective StudiesVisual Acuity

Identifiers

PMID39992662
PMCPMC11878244

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.