Evidence map›Paper›PMID 39992625›Full record

ArticleThe Journal of experimental medicine2025

Splicing factor RBM10 loss fuels thyroid cancer metastasis.

Kevin Coughlin, Ledong Wan

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kevin CoughlinDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY, USA.ORCID 0009-0007-3097-5924
Ledong WanDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY, USA.ORCID 0000-0002-2450-3986

Funding

American Cancer Society 21-143-01-IRGStony Brook University
6 · The paper itself

Abstract

In this issue of JEM, Krishnamoorthy et al. (https://doi.org/10.1084/jem.20241029) identify the loss of the splicing factor RBM10 as a driver of metastasis in thyroid cancer through the regulation of RNA splicing. The synthetic lethal interaction between NF-κB and RBM10 loss reveals a potential therapeutic vulnerability.

Indexed as

RNA-Binding ProteinsRNA SplicingThyroid NeoplasmsAnimalsGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisNF-kappa BNF-kappa BRBM10 protein, humanRNA-Binding Proteins

Identifiers

PMID39992625
PMCPMC11849749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.