Evidence map›Paper›PMID 39992621›Full record

ReviewTissue engineering and regenerative medicine2025

Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review.

Siyuan Chen, Zhenzhen Wu, Ziqi Huang, Chao Liang, Sang Jin Lee

Abstract readReview
In one paragraph

Review in Tissue engineering and regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic Review of Case Reports and Case Series Published Between 2015 and 2025 on the Use of Biomaterials for Closure of Oroantral Fistula.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Pooled it
  2. Materials advances in GTR membrane: A comprehensive review.Journal of Taibah University Medical Sciences · 2026
    Review
  3. Review
  4. Article
  5. Development and evaluation of a PLGA/TiOJournal of advanced periodontology & implant dentistry · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Cell-Cell or Cell-Biomaterial Interactions for Therapeutic Application.Tissue engineering and regenerative medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siyuan Chen *Biofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, People's Republic of China.
Zhenzhen Wu *Biofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, People's Republic of China.
Ziqi HuangBiofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, People's Republic of China.
Chao LiangBiofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, People's Republic of China.
Sang Jin LeeBiofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, People's Republic of China. dentsj@hku.hk.ORCID http://orcid.org/0000-0002-8007-8785

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT RS-2024- 00338610National R&D Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT RS-2024-00405574
6 · The paper itself

Abstract

backgroundPeriodontitis and bone loss in the maxillofacial and dental areas pose considerable challenges for both functional and aesthetic outcomes. To date, implantable dental barrier membranes, designed to prevent epithelial migration into defects and create a favorable environment for targeted cells, have garnered significant interest from researchers. Consequently, a variety of materials and fabrication methods have been explored in extensive research on regenerative dental barrier membranes.

methodsThis review focuses on dental barrier membranes, summarizing the various biomaterials used in membrane manufacturing, fabrication methods, and state-of-the-art applications for dental tissue regeneration. Based on a discussion of the pros and cons of current membrane strategies, future research directions for improved membrane designs are proposed. RESULTS AND

conclusionTo endow dental membranes with various biological properties that accommodate different clinical situations, numerous biomaterials and manufacturing methods have been proposed. These approaches provide theoretical support and hold promise for advancements in dental tissue regeneration.

Indexed as

Dental ImplantsDentistryMembranes, ArtificialRegenerative MedicineAnimalsBiocompatible MaterialsHumansBiocompatible MaterialsDental ImplantsMembranes, ArtificialDental membraneGTR/GBROral bioscienceOral tissue regenerationPeriodontal disease

Identifiers

PMID39992621
PMCPMC12122982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.