Evidence map›Paper›PMID 39992510›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Amino Acid Sensing by Transceptors: Exploring Substrate-Induced Regulation of Amino Acid Transporters and Transporter Expression.

Dinesh S Shah, Harinder S Hundal

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dinesh S ShahDivision of Cell Signalling and Immunology, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK.
Harinder S HundalDivision of Cell Signalling and Immunology, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK. h.s.hundal@dundee.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adaptation to changes in environmental availability of nutrients such as amino acids is crucial for cellular survival. Given the requirement of amino acids as building blocks for proteins and their capacity to induce activation of the mTORC1 pathway, which plays a vital role in regulating protein synthesis and cell growth, amino acid sensing in mammalian cells is understandably critical for cellular maintenance, growth, and proliferation. Members of the System A amino acid (AA) transporter family play an important role in mediating the sodium (Na

Indexed as

Amino AcidsAmino Acid Transport System AAmino Acid Transport SystemsAnimalsCell MembraneGene Expression RegulationHEK293 CellsHumansSodiumAmino AcidsAmino Acid Transport System AAmino Acid Transport SystemsSodiumAmino acid transporterAmino acid uptakeImmunoblotMethyl aminoisobutyrate (Me-AIB)Plasma membraneSodium (Na+)Total cell membrane isolation

Identifiers

PMID39992510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.