Evidence map›Paper›PMID 39992495›Full record

SynthesisClinical and experimental nephrology2025

Efficacy of drug-coated balloon versus uncoated balloon for dysfunctional dialysis access: a systematic review and meta-analysis.

Aarij Elahi, Momina Qamar, Fasih Mand Khan, Rameesha Babar, Muhammad Jawad Zahid, Muhammad Omar Ahmad, Shah Wali, Sharib Afzal, Moeen Ikram, Syed Ahsan Ali Shah and 5 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

15 authors.

Aarij ElahiRoyal Glamorgan Hospital, Pontyclun, UK.
Momina QamarCMH Lahore Medical College, Lahore, Pakistan.
Fasih Mand KhanFatima Memorial College of Medicine and Dentistry, Lahore, Pakistan.
Rameesha BabarBakhtawar Amin Medical College, Multan, Pakistan.
Muhammad Jawad ZahidHayatabad Medical Complex, Peshawar, Pakistan.
Muhammad Omar AhmadShalamar Hospital, Lahore, Pakistan.
Shah WaliMohtarma Shaheed Benazir Bhutto General Hospital, Quetta, Pakistan.
Sharib AfzalZiauddin Medical University, Karachi, Pakistan.
Moeen IkramFrontier Medical and Dental College, Abbottabad, Pakistan.
Syed Ahsan Ali ShahNorthwest General Hospital and Research Center, Peshawar, Pakistan.
Mohammad Ebad Ur RehmanDepartment of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan. ebadrehman.rehman@gmail.com.ORCID http://orcid.org/0000-0001-8118-4849
Huzaifa Ahmad CheemaDepartment of Nephrology, King Edward Medical University, Lahore, Pakistan. huzaifaahmadcheema@gmail.com.
Usama AnwarDepartment of Interventional Radiology, Boston Children's Hospital, Boston, MA, USA.
Muhammad Mohid TahirDepartment of Internal Medicine, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, New York, NY, USA.
Ioannis BellosDepartment of Nephrology and Renal Transplantation, Medical School, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDysfunctional vascular access is a major cause of morbidity and mortality in patients undergoing hemodialysis, affecting both arteriovenous fistulas and grafts. The most optimal strategy to restore long-term patency has not been established. This meta-analysis compares drug-coated balloon (DCB) versus uncoated balloon (UCB) angioplasty for dysfunctional vascular access.

methodsWe performed a systematic literature search across multiple databases from inception to June 2024. Randomized-controlled trials (RCTs) comparing DCB and UCB in dialysis patients with dysfunctional vascular access were included. Risk ratios were pooled using a random-effects model.

resultsTwenty-seven RCTs (2645 patients) were included. Target lesion patency (TLP) at 6 months was significantly superior in the DCB group (RR 1.22, 95% CI 1.07-1.39, p = 0.003). The two regimens were comparable for TLP at 3 months (RR 1.14, p = 0.24) and 12 months (RR 1.14, p = 0.10). The two regimens were comparable in terms of circuit patency rate, target-lesion revascularization, and all-cause mortality.

conclusionDCB has significantly superior TLP and a comparable risk of mortality to UCB. Further research is warranted to identify factors affecting outcomes following DCB angioplasty for dysfunctional dialysis access.

Indexed as

Angioplasty, BalloonArteriovenous Shunt, SurgicalCoated Materials, BiocompatibleGraft Occlusion, VascularRenal DialysisVascular Access DevicesHumansRandomized Controlled Trials as TopicTreatment OutcomeVascular PatencyCoated Materials, BiocompatibleBalloon angioplastyDCBDrug-coatedDysfunctional dialysis accessHemodialysis

Identifiers

PMID39992495

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.