Evidence map›Paper›PMID 39992468›Full record

ReviewVeterinary research communications2025

Contagious ecthyma in small ruminants: from etiology to vaccine challenges - a review.

Caroline Reichen, Breno Castello Branco Beirão, Alda Lúcia Gomes Monteiro

Abstract readReview
PubMed Publisher
In one paragraph

Review in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Caroline ReichenDepartment of Animal Science, Sheep and Goat Production and Research Center (LAPOC), Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil. caroline.reichen@ufpr.br.ORCID http://orcid.org/0000-0002-3299-1908
Breno Castello Branco BeirãoDepartment of Basic Pathology, Comparative Immunology Laboratory (LIC), Federal University of Paraná (UFPR), Curitiba, 81531-980, Paraná, Brazil.ORCID http://orcid.org/0000-0001-5870-1369
Alda Lúcia Gomes MonteiroDepartment of Animal Science, Sheep and Goat Production and Research Center (LAPOC), Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0001-5002-7832

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orf virus (ORFV) is an epitheliotropic, double-stranded DNA pathogen belonging to the genus Parapoxvirus, and it is the causative agent of contagious ecthyma (CE) in small ruminants. It is an endemic disease on goat and sheep herds around the world. It is often a neglected disease, with impacts on herd health and productivity, while also being an occupational zoonosis. This review explores the causative agent of ovine ecthyma, its epidemiology, and clinical manifestations, with a particular emphasis on its interaction with the host's immune system and the development of ORFV vaccines. Like other members of the Poxviridae family, ORFV expresses numerous immunomodulatory genes, which complicate vaccination efforts and disease management. This review highlights the challenges posed by ORFV in achieving effective immunization and discusses potential vaccine strategies to overcome these obstacles.

Indexed as

Ecthyma, ContagiousGoat DiseasesOrf virusSheep DiseasesViral VaccinesAnimalsGoatsSheepVaccinationViral VaccinesGoatImmune systemImmunomodulatory genesOrf virusSheepVaccine

Identifiers

PMID39992468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.