Observational studyIntensive care medicine2025
Ventilation practices in acute brain injured patients and association with outcomes: the VENTIBRAIN multicenter observational study.
Observational study in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Mechanical ventilation in acute brain injury.Breathe (Sheffield, England) · 2026Review
- Respiratory mechanics modifies the impact of ventilator settings on clinical outcome in patients with acute brain injury.Intensive care medicine · 2026Article
- ARDS management in trauma patients.Intensive care medicine · 2026Review
- Mechanical Ventilation Practices in Traumatic Brain Injury: A Systematic Review of Contemporary Evidence.Cureus · 2026Review
- Balancing lung and brain: physiological strategies for ARDS management in acute brain injury.Intensive care medicine · 2026Review
- Determinants of intensive care unit-acquired acute brain injury in acute respiratory distress syndrome: a retrospective cohort study of ventilator settings and patient factors.Journal of thoracic disease · 2026Article
- Analysis of the External Validity of the RAISE Score for Prediction of Prolonged Mechanical Ventilation in a United States-Based Cohort of Subarachnoid Hemorrhage Patients.Neurocritical care · 2026Article
- Dynamic driving pressure in acute brain injury: interpreting signals across ventilation modes and oxygenation severity-author's reply.Intensive care medicine · 2026Article
- Setting mechanical ventilation in patients with acute brain injury: ultra-low dynamic driving pressure for better outcomes?Intensive care medicine · 2026Article
- Effects of PEEP on ICP in ABI patients and its relationship with etiology.Intensive care medicine · 2026Article
- Spontaneous breathing trials as predictors of extubation outcomes in neurocritical care: insights from the ENIO study.Intensive care medicine · 2026Observational
- Individualized PEEP in acute brain injury: the overlooked impact of injury heterogeneity. Authors' reply.Intensive care medicine · 2026Article
- Development and validation of predicting hospital mortality of acute ischemic stroke patients over 80 years in ICU: a retrospective study.BMC geriatrics · 2026Article
- Early mobilization in neurocritical care as a threshold-regulated intervention: a narrative review of mechanistic integration and implications for neurological recovery and physiological stability.Frontiers in neurology · 2026Review
- Dynamic driving pressure and clinical outcomes in mechanically ventilated patients with acute brain injury: a secondary analysis of the VENTIBRAIN studyIntensive care medicine · 2026Observational
- Machine learning prediction models for mechanical ventilation requirement in patients with embolic stroke: a retrospective cohort study based on MIMIC-IV.Frontiers in medicine · 2026Article
- Bridging brain and lung: optimizing mechanical ventilation in acute brain injury.Journal of anesthesia, analgesia and critical care · 2025Review
- Pathophysiology and clinical applications of PEEP in acute brain injury.Intensive care medicine · 2025Review
- Brain Protective Ventilation Strategies in Severe Acute Brain Injury.Current neurology and neuroscience reports · 2025Review
- Capillary hemoglobin dynamics in COIntensive care medicine · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCurrent mechanical ventilation practices for patients with acute brain injury (ABI) are poorly defined. This study aimed to describe ventilator settings/parameters used in intensive care units (ICUs) and evaluate their association with clinical outcomes in these patients.
methodsAn international, prospective, multicenter, observational study was conducted across 74 ICUs in 26 countries, including adult patients with ABI (e.g., traumatic brain injury, intracranial hemorrhage, subarachnoid hemorrhage, and acute ischemic stroke), who required ICU admission and invasive mechanical ventilation. Ventilatory settings were recorded daily during the first week and on days 10 and 14. ICU and 6-months mortality and 6-months neurological outcome were evaluated.
resultsOn admission, 2095 recruited patients (median age 58 [interquartile range 45-70] years, 66.1% male) had a median plateau pressure (Pplat) of 15 (13-18) cmH
conclusionsProtective ventilation strategies are commonly used in ABI patients but with high variability across different countries. Ventilator settings during ICU stay were associated with an increased risk of ICU and 6-month mortality, but not an unfavorable neurological outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.