Evidence map›Paper›PMID 39992438›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Analysis of HNF1β expression suggests that its downregulation is involved in the sarcomatoid transformation of yolk sac tumor.

Costantino Ricci, Sofia Melotti, Luisa Di Sciascio, Francesca Ambrosi, Marco Grillini, Veronica Mollica, Michelangelo Fiorentino, Antonio De Leo, Muhammad T Idrees, Thomas M Ulbright and 1 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Costantino RicciPathology Unit, DIAP-Dipartimento Interaziendale Di Anatomia Patologica Di Bologna, Maggiore Hospital-AUSL Bologna, Via Dell'Ospedale 8, 40133, Bologna, Italy. costantino.ricci4@unibo.it.ORCID http://orcid.org/0000-0001-7254-4195
Sofia MelottiPathology Unit, DIAP-Dipartimento Interaziendale Di Anatomia Patologica Di Bologna, Maggiore Hospital-AUSL Bologna, Via Dell'Ospedale 8, 40133, Bologna, Italy.
Luisa Di SciascioDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0003-1809-3826
Francesca AmbrosiPathology Unit, DIAP-Dipartimento Interaziendale Di Anatomia Patologica Di Bologna, Maggiore Hospital-AUSL Bologna, Via Dell'Ospedale 8, 40133, Bologna, Italy.ORCID http://orcid.org/0000-0001-9046-1115
Marco GrilliniPathology Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Veronica MollicaMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-5169-3631
Michelangelo FiorentinoPathology Unit, DIAP-Dipartimento Interaziendale Di Anatomia Patologica Di Bologna, Maggiore Hospital-AUSL Bologna, Via Dell'Ospedale 8, 40133, Bologna, Italy.ORCID http://orcid.org/0000-0002-1749-150X
Antonio De LeoDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-3761-5135
Muhammad T IdreesDepartment of Pathology, Indiana University School of Medicine, Indianapolis, USA.ORCID http://orcid.org/0000-0001-6611-6389
Thomas M UlbrightDepartment of Pathology, Indiana University School of Medicine, Indianapolis, USA.
Andres Martin AcostaDepartment of Pathology, Indiana University School of Medicine, Indianapolis, USA.ORCID http://orcid.org/0000-0003-0164-5911

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcomatoid yolk sac tumor postpubertal-type (YSTpt) is a rare phenotype of germ cell tumor that occurs mostly after chemotherapy. Its diagnosis is clinically relevant but challenging, due to its somewhat inconspicuous histologic features and negative/low expression of classical YSTpt makers (α-fetoprotein (AFP), glypican-3 (GPC3), and GATA3)). HNF1β is likely a key inducer of the YSTpt phenotype, acting in part by regulating the binding of FOXA2 to its target genomic sequences. Recently, immunohistochemical studies have shown that HNF1β has a sensitivity comparable to FOXA2 (higher than GPC3 and AFP) for non-sarcomatoid YSTpt. We found that sarcomatoid YSTpt did not express HNF1β (0: 8/8 (100%)), suggesting that combined downregulation of FOXA2 and HNF1β may underlie the sarcomatoid transformation in this rare phenotype of germ cell tumor.

Indexed as

Biomarkers, TumorCell Transformation, NeoplasticEndodermal Sinus TumorHepatocyte Nuclear Factor 1-betaOvarian NeoplasmsSarcomaDown-RegulationFemaleHepatocyte Nuclear Factor 3-betaHumansImmunohistochemistryMaleBiomarkers, TumorFOXA2 protein, humanHepatocyte Nuclear Factor 1-betaHepatocyte Nuclear Factor 3-betaHNF1B protein, humanFOXA2HNF1βSarcomatoid yolk sac tumor postpubertal-typeSomatic-type malignancyYolk sac tumor postpubertal-type

Identifiers

PMID39992438

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.