Evidence map›Paper›PMID 39992415›Full record

ArticleJournal of gastroenterology2025

Diagnostic performance of attenuation imaging versus controlled attenuation parameter for hepatic steatosis with MRI-based proton density fat fraction as the reference standard: a prospective multicenter study.

Takashi Nishimura, Toshifumi Tada, Tomoyuki Akita, Reiichiro Kondo, Yasuaki Suzuki, Kento Imajo, Shigehiro Kokubu, Tamami Abe, Hidekatsu Kuroda, Masashi Hirooka and 15 more

Abstract readMulticenter StudyComparative Study
In one paragraph

Article in Journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Takashi NishimuraDivision of Hepatobiliary and Pancreatic Disease, Department of Gastroenterology, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya, Japan.
Toshifumi TadaDepartment of Internal Medicine, Japanease Red Cross Himeji Hospital, Himeji, Japan.
Tomoyuki AkitaDepartment of Epidemiology, Infectious Disease Control, and Prevention, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Reiichiro KondoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Yasuaki SuzukiDepartment of Gastroenterology, Nayoro City General Hospital, Nayoro, Japan.
Kento ImajoDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Shigehiro KokubuDepartment of Gastroenterology, Shin-Yurigaoka General Hospital, Kawasaki, Japan.
Tamami AbeDivision of Hepatology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
Hidekatsu KurodaDivision of Hepatology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
Masashi HirookaDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan.
Yoichi HiasaDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan.
Asako NogamiDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Atsushi NakajimaDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Sadanobu OgawaDepartment of Clinical Research, Ogaki Municipal Hospital, Ogaki, Japan.
Hidenori ToyodaDepartment of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan.
Satoshi OedaLiver Center, Saga Medical School, Saga University, Saga, Japan.
Hirokazu TakahashiLiver Center, Saga Medical School, Saga University, Saga, Japan.
Yuichiro EguchiLiver Center, Saga Medical School, Saga University, Saga, Japan.
Katsutoshi SugimotoDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Hirohisa YanoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Junko TanakaDepartment of Epidemiology, Infectious Disease Control, and Prevention, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.
Fuminori MoriyasuDepartment of Gastroenterology and Hepatology, International University of Health and Welfare, Sanno Hospital, Tokyo, Japan.
Masayoshi KageCenter for Innovative Cancer Therapy, Kurume University Research, Kurume, Japan.
Takashi KumadaDepartment of Nursing, Gifu Kyoritsu University, Ogaki, Japan.
Hiroko IijimaDivision of Hepatobiliary and Pancreatic Disease, Department of Gastroenterology, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya, Japan. hiroko-i@hyo-med.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAttenuation Imaging (ATI) and controlled attenuation parameter (CAP) are non-invasive ultrasound-based methods for diagnosing hepatic steatosis. However, reports on the clinical usefulness of ATI are limited. We aimed to compare the ability of ATI and CAP to diagnose hepatic steatosis with magnetic resonance imaging-based proton density fat fraction (MRI-PDFF) as the reference standard.

methodsWe performed a prospective multicenter study of 562 patients with chronic liver disease who underwent ATI, CAP, and MRI-PDFF. Patients with skin-to-liver capsule distance (SCD) ≤ 25 mm underwent CAP with an M probe; those with SCD > 25 mm underwent CAP with an XL probe. MRI-PDFF was used as the reference standard: S0 corresponds to MRI-PDFF < 5.2%, S1 to 5.2% ≤ MRI-PDFF < 11.3%, S2 to 11.3% ≤ MRI-PDFF < 17.1%, and S3 to MRI-PDFF ≥ 17.1%.

resultsThe correlation coefficients for ATI and MRI-PDFF stratified by body mass index (< 30, ≥ 30 kg/m

conclusionsATI is a more useful non-invasive method for diagnosing hepatic steatosis than CAP.

Indexed as

Fatty LiverMagnetic Resonance ImagingAdultAgedFemaleHumansLiverMaleMiddle AgedProspective StudiesReference StandardsUltrasonography2-dimensional share wave elastography (2D-SWE)Attenuation imaging (ATI)Controlled attenuation parameter (CAP)Hepatic steatosisMagnetic resonance imaging-based proton density fat fraction (MRIPDFF)

Identifiers

PMID39992415
PMCPMC12095409

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.