Evidence map›Paper›PMID 39992135›Full record

Trial reportmSphere2025

Neonatal administration of

Lisa G Pell, Huma Qamar, Diego G Bassani, Cole Heasley, Celine Funk, Chun-Yuan Chen, Jakaria Shawon, Karen M O'Callaghan, Eleanor Pullenayegum, Davidson H Hamer and 16 more

Registry-linked trialAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05180201 (Safety, Tolerability and Effects on the Microbiome of Neonatal Administration of Lactiplantibacillus Plantarum ATCC 202195 With or Without Fructooligosaccharide for One or Seven Days), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05180201 phase2completednot on this map

Safety, Tolerability and Effects on the Microbiome of Neonatal Administration of Lactiplantibacillus Plantarum ATCC 202195 With or Without Fructooligosaccharide for One or Seven Days: a Phase II Randomized Placebo-controlled Trial in Dhaka, Bangladesh

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2022 to 2022Enrolled519ConditionsMicrobial Colonization, Tolerance, Safety Issues, Infant ALLArmsSynbiotic, Probiotic, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Neonatal faecal abundance ofGut microbiome (Cambridge, England) · 2026
    Article
  2. Article
  3. Article
  4. Environmental and Maternal Imprints on Infant Gut Metabolic Programming.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Lisa G PellCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-5116-9998
Huma QamarCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Diego G BassaniCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Cole HeasleyCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Celine FunkCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Chun-Yuan ChenCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Jakaria ShawonNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Karen M O'CallaghanDepartment of Nutritional Sciences, King's College London, London, United Kingdom.
Eleanor PullenayegumChild Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, Canada.
Davidson H HamerDepartment of Global Health, Boston University School of Public Health and Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Rashidul HaqueNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Mamun KabirNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Tahmeed AhmedNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Ciobha O'KellyCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Md Iqbal HossainNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Afreen Z KhanCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Miranda G LoutetCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Mohammad Shahidul IslamChild Health Research Foundation, Dhaka, Bangladesh.
Shaun K MorrisCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Prakesh S ShahDepartment of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Philip M ShermanDepartment of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Shamima SultanaNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Abdullah Al MahmudNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Samir K SahaChild Health Research Foundation, Dhaka, Bangladesh.
Shafiqul A SarkerNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Daniel E RothCentre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-7742-0925

Funding

Bill and Melinda Gates Foundation (GF) GR-02268Gates Foundation INV-007389
6 · The paper itself

Abstract

IMPORTANCE: Among infants born in Dhaka, Bangladesh, a 7-day regimen of CLINICAL TRIALS: This study has been registered at ClinicalTrials.gov as NCT05180201.

Indexed as

Lactiplantibacillus plantarumNeonatal SepsisOligosaccharidesProbioticsBangladeshFecesFemaleGastrointestinal MicrobiomeHumansInfantInfant, NewbornMalePlacebosfructooligosaccharideOligosaccharidesPlaceboscolonizationdeveloping countrieslactobacillineonateprobioticrandomized controlled trialsafetysevere infectionsynbiotictolerability

Identifiers

PMID39992135
PMCPMC11934310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.