Evidence map›Paper›PMID 39992049›Full record

ArticleCNS neuroscience & therapeutics2025

Physical Activities and Parkinson's Disease Progression: A Two-Sample Mendelian Randomization Study.

Xiaoyue Luo, Cheng Xue, Yongli Pan, Wei Wei, Zhongnan Hao, Zheng Liu, Zijian Zheng, Guohui Lu, Zhipeng Xiao, Meihua Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoyue LuoDepartment of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Cheng XueJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yongli PanDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.
Wei WeiDepartment of Neurology, The Affiliated Hospital of Southwest Jiaotong University & the Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
Zhongnan HaoDepartment of Neurology, University of Göttingen Medical School, Göttingen, Germany.
Zheng LiuJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zijian ZhengJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Guohui LuJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhipeng XiaoJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Meihua LiJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Wenqiang XinJiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID 0000-0003-0231-6474

Funding

Young Scholar Project of the First Affiliated Hospital of Nanchang University YFYPY202404
6 · The paper itself

Abstract

aimsTo explore the causal relationship between physical activity (PA) and the progression of Parkinson's disease (PD), we conducted a two-sample Mendelian randomization (MR) analysis.

methodsGenetic variants were obtained from publicly available genome-wide association study (GWAS) summary statistics for PA (N = 377,000), age at onset (N = 28,568), and PD progression (N = 4093). Causal estimates were calculated using the inverse variance weighted (IVW) method, with MR-Egger and weighted median analyses performed to assess the robustness of the results.

resultsGenetically predicted accelerometer-based overall acceleration average (OAA) was associated with a reduced risk of constipation in PD progression (OR: 0.60, 95% CI: 0.42-0.86, p = 5.50 × 10

conclusionOur findings suggest a negative causal relationship between PA and PD progression, highlighting the potential role of physical activity in guiding therapeutic strategies for PD management.

Indexed as

Disease ProgressionExerciseMendelian Randomization AnalysisParkinson DiseaseAccelerometryConstipationGenome-Wide Association StudyHumansMaleage at onsetMendelian randomizationParkinson's diseasephysical activityprogression

Identifiers

PMID39992049
PMCPMC11848732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.