ArticleNutrition bulletin2025
Associations Between Chrono-Nutrition Behaviours and Cognitive Function in Middle-Aged Adults: The NUTRICO Cross-Sectional Cohort Study.
Article in Nutrition bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07378787 (The Effect of Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Markers of Biological Age and Metabolic Health in Late-Perimenopausal and Menopausal Women), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Markers of Biological Age and Metabolic Health in Late-Perimenopausal and Menopausal Women: a Randomized Controlled Trial. The NutriAge Trial.
Who cites it
2 citing papers in PubMed.
- Late-night dinner, skipping breakfast, and the risk of dementia in Japan: the LIFE Study.GeroScience · 2026Article
- Nutritional interventions for late-life depression: evidence, mechanisms, and clinical assessment tools.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy midlife cognitive function (CF) reduces the risk of later cognitive decline. Emerging evidence suggests that chrono-nutrition may be associated with CF. This cross-sectional cohort study aimed to examine associations between chrono-nutrition behaviours and CF in adults aged 45-65 years living in Cyprus. Chrono-nutrition, including misalignments between actual and preferred eating times, Mediterranean diet (MD) adherence, sleep and physical activity were assessed using validated questionnaires. Computerised neurocognitive remote testing was used to derive standard normalised age-matched scores for composite memory, psychomotor speed, cognitive flexibility, complex attention, reaction time and neurocognitive index. Education, marital status, smoking, body mass index, chronic disease diagnosis and religious fasting were also assessed. Adjusted multivariate ordinal logistic regression was used to assess each chrono-nutrition variable against each cognitive outcome. Two-hundred and seven participants were analysed (58% female, median age: 52 years, 75.6% university graduates). Morning latency (duration of time between one's wake time and first eating event) misalignment was associated with higher neurocognitive index (OR eating later than preferred by 30-90 min: 2.91; 95% CI: 1.33-5.97 and OR eating later than preferred by > 90 min: 2.57; 95% CI: 1.34-4.88) and with higher cognitive flexibility (OR eating later than preferred by 30-90 min: 2.23; 95% CI: 1.07-4.64). An eating window longer than preferred by > 120 min was associated with a lower psychomotor speed (OR: 0.17; 95% CI: 0.04-0.67). Evening eating between 20:00 and 22:59 versus before 20:00 was associated with higher complex attention (OR: 2.07; 95% CI: 1.08-3.97). No evidence was found that eating alignment is associated with better CF. The study provides insights that some chrono-nutrition behaviours may be associated with CF with potential implications for improving CF in middle-aged adults.
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Registered trials
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