ArticleThe Journal of physiology2025
Modulation of cardiomyocyte contractility and action potentials with chemogenetic chloride currents.
Muhammed Sönmez, Tim Stüdemann, Christoph Manthey, Anita Covic, Nancy Shehata, Junsoo Im, Barbora Schwarzova, Judith Rössinger, Rajiven Srikantharajah, Aya Shibamiya and 4 more
Abstract read
In one paragraphArticle in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Muhammed SönmezInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0009-0004-6040-3757 Tim StüdemannInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christoph MantheyInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anita CovicInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nancy ShehataInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-7576-1969 Junsoo ImInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Barbora SchwarzovaInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-7663-7647 Judith RössingerInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-0801-7283 Rajiven SrikantharajahInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Aya ShibamiyaInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Edzard SchwedhelmGerman Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.ORCID 0000-0003-3597-6276 Thomas EschenhagenInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Torsten ChristInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-8935-5304 Florian WeinbergerInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1961-0517 Funding
EC | Horizon 2020 Framework Programme (H2020) 874764EC | Horizon 2020 Framework Programme (H2020) 964800Philipp Schwartz Initiative of the Alexander von HumboldtWerner Otto Stiftung (Werner-Otto-Stiftung)
6 · The paper itselfAbstract
Transient perturbation of electrical activity is used in neuroscience to study the impact of specific neuronal cell populations on brain function. Similarly, cardiomyocyte (CM) physiology can be controlled by the activation of artificially expressed ion channels. Pharmacologically selective actuator modules (PSAMs) are engineered ligand-gated ion channels that can be activated with small molecules. We aimed to use the 'inhibitory' PSAMs, (i) PSAM
Indexed as
Action PotentialsChloride ChannelsMyocardial ContractionMyocytes, CardiacReceptors, GlycineAnimalsChemogeneticsChloridesHumansInduced Pluripotent Stem CellsChloride ChannelsChloridesReceptors, Glycinecardiac electrophysiologycardiac functioncardiomyocytechemogeneticspluripotent stem cells
Identifiers
PMID39992007
PMCPMC11908473
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