Evidence map›Paper›PMID 39991932›Full record

ReviewACS applied materials & interfaces2025

Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.

Linley Li Lin, Ramon Alvarez-Puebla, Luis M Liz-Marzán, Matt Trau, Jing Wang, Laura Fabris, Xiang Wang, Guokun Liu, Shuping Xu, Xiao Xia Han and 37 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Geometry-Controlled Assembly of Self-Standing Nanorods With Undisturbed Plasmonics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. SERS-Based Nano- and Microsystems Toward Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Linley Li LinSixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.ORCID 0000-0002-8079-5768
Ramon Alvarez-PueblaDepartamento de Química Física e Inorganica, Universitat Rovira i Virgili, Tarragona 43007, Spain.ORCID 0000-0003-4770-5756
Luis M Liz-MarzánCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián 20014, Spain.ORCID 0000-0002-6647-1353
Matt TrauCentre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-5516-1280
Jing WangKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350117, China.ORCID 0000-0001-6080-7998
Laura FabrisDepartment of Applied Science and Technology, Politecnico di Torino Corso Duca degli Abruzzi 24, 10129 Torino, Italy.ORCID 0000-0002-7089-5175
Xiang WangState Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.ORCID 0000-0003-1937-0725
Guokun LiuState Key Laboratory of Marine Environmental Science, Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, Center for Marine Environmental Chemistry and Toxicology, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China.ORCID 0000-0003-2501-7178
Shuping XuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.ORCID 0000-0002-6216-6175
Xiao Xia HanState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.ORCID 0000-0002-0544-4351
Liangbao YangInstitute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China.ORCID 0000-0002-6559-6947
Aiguo ShenSchool of Bioengineering and Health, Wuhan Textile University, Wuhan 430200, P. R. China.
Shikuan YangSchool of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.ORCID 0000-0001-6662-3057
Yikai XuKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.ORCID 0000-0003-3881-8871
Chunchun LiSchool of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.ORCID 0000-0001-9501-0313
Jinqing HuangDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong 999077, China.
Shao-Chuang LiuMolecular Sensing and Imaging Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.ORCID 0000-0002-1010-2321
Jian-An HuangResearch Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Aapistie 5 A, 90220 Oulu, Finland.ORCID 0000-0002-6564-5972
Indrajit SrivastavaDepartment of Mechanical Engineering, Texas Tech University, Lubbock, Texas 79409, United States.ORCID 0000-0002-6864-0202
Ming LiSchool of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, China.ORCID 0000-0002-2289-0222
Limei TianDepartment of Biomedical Engineering, and Center for Remote Health Technologies and Systems Texas A&M University, College Station, Texas 77843, United States.ORCID 0000-0002-1931-8567
Lam Bang Thanh NguyenSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.
Xinyuan BiSixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.
Dana Cialla-MayLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre for Photonics in Infection Research (LPI), Albert-Einstein-Straße 9, 07745 Jena, Germany.
Pavel MatousekCentral Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, UKRI, Harwell Campus, Oxfordshire OX11 0QX, United Kingdom.ORCID 0000-0003-0912-5339
Nicholas StoneDepartment of Physics and Astronomy, University of Exeter, Exeter EX4 4QL, United Kingdom.ORCID 0000-0001-5603-3731
Randy P CarneyDepartment of Biomedical Engineering, University of California, Davis, California 95616, United States.ORCID 0000-0001-8193-1664
Wei JiCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 145040, China.ORCID 0000-0001-6391-9768
Wei SongState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.ORCID 0000-0001-9814-419X
Zhou ChenSixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.ORCID 0000-0002-3018-8169
In Yee PhangKey Laboratory of Synthetic and Biological Colloids, Ministry of Education, International Joint Research Laboratory for Nano Energy Composites, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, P. R. China.
Malou Henriksen-LaceyCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián 20014, Spain.ORCID 0000-0003-3544-5846
Haoran ChenSixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.
Zongyu WuSixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.
Heng GuoDepartment of Biomedical Engineering, and Center for Remote Health Technologies and Systems Texas A&M University, College Station, Texas 77843, United States.
Hao MaState Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.ORCID 0000-0001-8341-4003
Gennadii UstinovLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre for Photonics in Infection Research (LPI), Albert-Einstein-Straße 9, 07745 Jena, Germany.
Siheng LuoState Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Sara MoscaCentral Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, UKRI, Harwell Campus, Oxfordshire OX11 0QX, United Kingdom.ORCID 0000-0001-9479-5614
Benjamin GardnerDepartment of Physics and Astronomy, University of Exeter, Exeter EX4 4QL, United Kingdom.ORCID 0000-0002-7223-9585
Yi-Tao LongMolecular Sensing and Imaging Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.ORCID 0000-0003-2571-7457
Juergen PoppLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre for Photonics in Infection Research (LPI), Albert-Einstein-Straße 9, 07745 Jena, Germany.ORCID 0000-0003-4257-593X
Bin RenState Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.ORCID 0000-0002-9821-5864
Shuming NieDepartment of Bioengineering, University of Illinois at Urbana-Champaign, 1406 W. Green Street, Urbana, Illinois 61801, United States.ORCID 0000-0002-7328-1144
Bing ZhaoState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.ORCID 0000-0002-0044-9743
Xing Yi LingSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.ORCID 0000-0001-5495-6428
Jian YeSixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.ORCID 0000-0002-8101-8362

Funding

SERS diagnostics platform for liquid bioapsy analysis of tumor-associated exosomesR01CA241666 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARNEY, RANDY · 2020 to 2024
$2.5M
Continuous metabolite and protein profiling for immune monitoringR35GM147568 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Limei Tian · 2022 to 2026
$1.8M
NCI NIH HHS R01 CA241666NIGMS NIH HHS R35 GM147568
6 · The paper itself

Abstract

The year 2024 marks the 50th anniversary of the discovery of surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity and molecular specificity. This review summarizes the advancements and challenges in SERS substrates, nanotags, instrumentation, and spectral analysis for biomedical applications. We highlight the key developments in colloidal and solid SERS substrates, with an emphasis on surface chemistry, hotspot design, and 3D hydrogel plasmonic architectures. Additionally, we introduce recent innovations in SERS nanotags, including those with interior gaps, orthogonal Raman reporters, and near-infrared-II-responsive properties, along with biomimetic coatings. Emerging technologies such as optical tweezers, plasmonic nanopores, and wearable sensors have expanded SERS capabilities for single-cell and single-molecule analysis. Advances in spectral analysis, including signal digitalization, denoising, and deep learning algorithms, have improved the quantification of complex biological data. Finally, this review discusses SERS biomedical applications in nucleic acid detection, protein characterization, metabolite analysis, single-cell monitoring, and

Indexed as

Spectrum Analysis, RamanAnimalsHumansSurface Propertiesmetabolic detectionnanomedicineplasmonicsRaman scatteringSERSometransmission Raman spectroscopy

Identifiers

PMID39991932
PMCPMC12184206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.