Evidence map›Paper›PMID 39991929›Full record

ArticleeLife2025

Improved base editing and functional screening in

Nicole Herrmann May, Anh Cao, Annika Schmid, Fabian Link, Jorge Arias-Del-Angel, Elisabeth Meiser, Tom Beneke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. CRISPR-Cas13b mediated gene knockdowns in Leishmania infantum.International journal for parasitology. Drugs and drug resistance · 2025
    Article
  3. Review
  4. Recent advances in the genetic engineering of theIranian journal of basic medical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicole Herrmann MayDepartment of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, Würzburg, Germany.
Anh CaoDepartment of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, Würzburg, Germany.
Annika SchmidDepartment of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, Würzburg, Germany.
Fabian LinkDepartment of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, Würzburg, Germany.ORCID https://orcid.org/0000-0002-9828-2012
Jorge Arias-Del-AngelDepartment of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, Würzburg, Germany.
Elisabeth MeiserDepartment of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, Würzburg, Germany.
Tom BenekeDepartment of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, Würzburg, Germany.ORCID https://orcid.org/0000-0001-9117-2649

Funding

Deutsche Forschungsgemeinschaft 532631727European Molecular Biology Organization ALTF 727-2021HORIZON EUROPE Marie Sklodowska-Curie Actions 101064428 - LeishMOMLOEWE Center DRUID Project D3 and B3
6 · The paper itself

Abstract

The ability to analyze the function of all genes in a genome is highly desirable, yet challenging in

Indexed as

CytosineDNA-Directed RNA PolymerasesGene EditingLeishmaniaViral Proteinsbacteriophage T7 RNA polymeraseCytosineDNA-Directed RNA PolymerasesViral ProteinsCas12aCRISPRcytosine base editingfunctional screeninggeneticsgenomicsinfectious diseaseLeishmanialoss-of-functionmicrobiology

Identifiers

PMID39991929
PMCPMC11850003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.