Evidence map›Paper›PMID 39991834›Full record

ArticleeLife2025

Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish.

Wenqing Li, Sara McCurdy, Miguel A Lopez-Ramirez, Ho-Sup Lee, Mark H Ginsberg

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wenqing LiDepartment of Medicine, University of California, San Diego, San Diego, United States.ORCID https://orcid.org/0000-0002-2721-8603
Sara McCurdyDepartment of Medicine, University of California, San Diego, San Diego, United States.
Miguel A Lopez-RamirezDepartment of Medicine, University of California, San Diego, San Diego, United States.
Ho-Sup LeeDepartment of Medicine, University of California, San Diego, San Diego, United States.
Mark H GinsbergDepartment of Medicine, University of California, San Diego, San Diego, United States.

Funding

The Hemostasis, Thrombosis, and Inflammation Models CoreP01HL151433 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark HOWARD Ginsberg · 2020 to 2026
$16.4M
Somatic mutation(s) and cellular changes in CCM pathogenesisP01NS092521 · NINDS · DUKE UNIVERSITY · PI KAHN, MARK L · 2015 to 2024
$12.9M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
Mechanisms of hypoxia induced exacerbation of cerebral cavernous malformationsR01NS121070 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Miguel Alejandro Lopez-Ramirez · 2022 to 2026
$2.3M
NHLBI NIH HHS P01 HL151433NHLBI NIH HHS T32 HL115505NIH HHS P01 HL151433NIH HHS P01 NS092521NINDS NIH HHS P01 NS092521NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS121070
6 · The paper itself

Abstract

Previously, we showed that propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (CVP) lesions in zebrafish that follow mosaic inactivation of

Indexed as

Hemangioma, Cavernous, Central Nervous SystemReceptors, Adrenergic, beta-1ZebrafishZebrafish ProteinsAnimalsDisease Models, AnimalMetoprololPropranololMetoprololPropranololReceptors, Adrenergic, beta-1Zebrafish Proteinsbeta1 adrenergic receptorbeta1 selective antagonistcerebral cavernous malformationdevelopmental biologyvascular biologyzebrafish

Identifiers

PMID39991834
PMCPMC11849999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.