Evidence map›Paper›PMID 39991782›Full record

ArticleJournal of the American Chemical Society2025

Photoenolization of

Kuei-Chen Chang, Hung-Hsuan Chiu, Pin-Gong Huang, Shinje Miñoza, Wen-Hsuan Lee, Prem Kumar Keerthipati, Sasirome Racochote, Yi-Hua Lee, Chih-Ju Chou, Che-Ming Hsu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Enantioselective Contrathermodynamic Olefin Isomerization.Journal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kuei-Chen ChangDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Hung-Hsuan ChiuDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Pin-Gong HuangDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Shinje MiñozaDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Wen-Hsuan LeeDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Prem Kumar KeerthipatiDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Sasirome RacochoteDepartment of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Yi-Hua LeeDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Chih-Ju ChouDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Che-Ming HsuDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Che-Wei ChangDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Darunee SoorukramDepartment of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-6865-2270
Cheng-Chau ChiuDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).
Hsuan-Hung LiaoDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (R.O.C.).ORCID 0000-0001-7825-2425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enantioselective protonation of prochiral enolates is an ideal and straightforward platform to synthesize stereodefined α-tertiary esters, which are recurring motifs in a myriad of biorelevant molecules and important intermediates thereof. However, this approach remains onerous, particularly when dealing with α-unactivated esters and related acids, as enantioinduction on the nascent nucleophile necessitates peremptory reaction conditions, thus far only achieved via preformed enolates. A complementary and contra-thermodynamic catalytic strategy is herein described, where a transient photoenol, in the form of a ketene hemiacetal, is enantioselectively protonated with a chiral phosphoric acid (CPA). The prochiral photoketene hemiacetals are procured from excited

Identifiers

PMID39991782
PMCPMC11887454

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.