ReviewInternational journal of medical sciences2025
Clusterin: structure, function and roles in disease.
Review in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- COPS7B Drives Malignant Progression of Glioblastoma Through Translational Upregulation of the Downstream Functional Effector CLU.International journal of molecular sciences · 2026Article
- Bioinformatics identification of candidate biomarkers associated with T cell proliferation in atherosclerosis via WGCNA and machine learning.Journal of cardiothoracic surgery · 2026Article
- Adipose precursor cell-derived clusterin promotes homeostasis in subcutaneous adipose tissue.Stem cell reports · 2026Article
- Non-Invasive Biomarkers for Assessing Liver Fibrosis in Biliary Atresia: A Literature Review.International journal of molecular sciences · 2026Review
- Healthy lifestyle and Alzheimer's disease in individuals with hyperlipidemia: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Antioxidant Role of High-Density Lipoprotein.Antioxidants (Basel, Switzerland) · 2026Article
- Diagnostic Value and Metabolic Association of Serum Clusterin in Women with Polycystic Ovary Syndrome.Diagnostics (Basel, Switzerland) · 2026Article
- Alterations of Apolipoprotein A1, E, and J Genes in the Frontal Cortex in an Ischemic Model of Alzheimer's Disease with 2-Year Survival.International journal of molecular sciences · 2025Article
- Peptidomics analysis of serum in patients suffered from generalized anxiety disorder.Scientific reports · 2025Article
- The Emerging Role of the Molecular Chaperone Clusterin in Parkinson's Disease.International journal of molecular sciences · 2025Review
- Integrated transcriptomic and proteomic analyses identify the TLR2-CXCR4 axis as a regulator of endothelial cell migration under simulated microgravity.Frontiers in physiology · 2025Article
- Machine learning-driven identification of exosome- related biomarkers in head and neck squamous cell carcinoma.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clusterin (CLU) is a glycoprotein that exists in various forms in cells, including nuclear, cytoplasmic, and secreted types. The relative molecular weight of CLU varies significantly due to differences in glycosylation and cleavage. Although CLU is commonly present in mammalian tissues and body fluids, its expression levels differ markedly under physiological and pathological conditions. The existence forms and molecular sizes of CLU in cells vary greatly, contributing to its diverse functions. For example, CLU can participate in the occurrence and development of neurological, fibrotic, and metabolic diseases by regulating cell endocytosis, apoptosis, and other processes. This article will review the structural characteristics, basic functions, and potential regulatory mechanisms of CLU protein in physiological and pathological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.