Evidence map›Paper›PMID 39991757›Full record

ArticleInternational journal of medical sciences2025

Identifying Water-Salt Homeostasis and Inflammatory Response in Pathological Cardiac Surgery-Associated Acute Kidney Injury: NT-proBNP-related lncRNAs and miRNAs as Novel Diagnostic Biomarkers and Therapeutic Targets.

Bianfang Li, Jianhui Wang, Yuchen Gao, Xiaojing Wu, Chunrong Wang, Jin Wang, Jia Liu, Yuefu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bianfang LiDepartment of Surgery Intensive Care Unit, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Jianhui WangDepartment of Anesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Yuchen GaoDepartment of Anesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Xiaojing WuDepartment of Surgery Intensive Care Unit, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Chunrong WangDepartment of Anesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Jin WangXianning Medical College, Hubei University of Science & Technology, Xianning 437000, China.
Jia LiuDepartment of Anesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Yuefu WangDepartment of Surgery Intensive Care Unit, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury related to cardiac surgery (CS-AKI) is a serious medical issue that creates significant social and economic challenges globally. Inflammatory responses and disruptions in water and salt balance are important contributors to CS-AKI. Earlier studies indicated that pre-surgery levels of NT-proBNP were a dependable indicator of CS-AKI. Emerging evidence indicates that the abnormal expression of microRNA (miRNA) and long non-coding RNA (lncRNA) plays a role in the occurrence of CS-AKI. However, the important roles and mechanisms by which NT-proBNP affects lncRNA and miRNA in CS-AKI are still unclear. Here, we investigated lncRNA and miRNA expression patterns in BNP-high, BNP-stable, AKI, and non-AKI groups through whole transcriptome sequencing analysis. The BNP group exhibited differential expressions of 105 miRNAs and 138 lncRNAs. We identified 7 common miRNAs and lncRNAs in both the BNP and AKI groups. A functional and pathway enrichment analysis of the target genes associated with these miRNAs and lncRNAs was conducted, indicating that miR-135a-5p, miR-138-5p, miR-143-3p, and miR-206 are key factors in CS-AKI, particularly in regulating inflammatory responses and water-salt balance. These results provide fresh perspectives on research directions and possible treatment approaches for CS-AKI.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresMicroRNAsNatriuretic Peptide, BrainPeptide FragmentsPostoperative ComplicationsRNA, Long NoncodingAgedBiomarkersFemaleGene Expression ProfilingHomeostasisHumansInflammationMaleMiddle AgedBiomarkersMicroRNAsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)RNA, Long NoncodingCS-AKIlncRNAmiRNANT-proBNPRNA-sequencing

Identifiers

PMID39991757
PMCPMC11843142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.