Evidence map›Paper›PMID 39991704›Full record

ArticleCytotechnology2025

E2F2 induces microglial activation and augments depressive-like behavior in mice by repressing PTPN6 transcription.

Jiali Xin, Yao Chen, Leijing Zhang, Lan Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. E2F2 inhibits hippocampal neurogenesis in poststroke depression rats via the miR-1290/CBR1 axis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiali Xin *Department of Psychiatry and Psychology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin, 150001 Heilongjiang P.R. China.
Yao Chen *Department of Psychiatry and Psychology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin, 150001 Heilongjiang P.R. China.
Leijing ZhangDepartment of Psychiatry and Psychology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin, 150001 Heilongjiang P.R. China.
Lan MaDepartment of Psychiatry and Psychology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin, 150001 Heilongjiang P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is the leading contributor to disability and suicide ideation. Informed by the insights from bioinformatics analyses, this study investigates the roles of E2F transcription factor 2 (E2F2) and protein tyrosine phosphatase non-receptor type 6 (PTPN6) in the activation of microglia and the manifestation of depressive-like behavior in mice. Chronic unpredictable mild stress was applied

Indexed as

DepressionE2F2MiceMicrogliaPTPN6

Identifiers

PMID39991704
PMCPMC11845659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.