ArticleOsteoarthritis and cartilage open2025
Clinical phenotypes and associated factors in knee osteoarthritis in an African black population.
Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Assessment of vitamin E status among patients with newly diagnosed primary knee osteoarthritis in Cameroon.Scientific reports · 2026Article
- A retrospective predictive model for worsening knee osteoarthritis pain by integrating baseline gait biomechanics and wearable gait parameters.American journal of translational research · 2026Article
- Integrative Phenotyping of Knee Osteoarthritis: Linking WOMAC Cut-Offs, Kellgren-Lawrence Grades, and Cluster Analysis for Personalized Care.Life (Basel, Switzerland) · 2025Article
- Preoperative Clinical Phenotyping for Individualised Rehabilitation in End-Stage Knee Osteoarthritis.Journal of functional morphology and kinesiology · 2025Article
- Grip Strength Impairment and Neuropathic-Like Pain as Predictors of Functional Decline in Hand Osteoarthritis.Open access rheumatology : research and reviews · 2025Article
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Authors and funding
8 authors.
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Abstract
Objective: Our objective was to study the clinical phenotypes of knee osteoarthritis in rheumatology in a black sub-Saharan African population. Methods: This study took place from October 1, 2022, to September 30, 2023, in the rheumatology department. It involved adult patients with knee osteoarthritis. The researchers used K-means clustering analysis to identify different phenotypes and logistic regression to determine associated factors. Results: A total of 321 patients were included in the study. The mean age was 58.7 years (ranging from 21 to 92 years), with a sex ratio of 0.23 (M/F). The study identified five clinical phenotypes through clustering: 152 patients (47.3 %) exhibited the "osteoporotic" phenotype, 113 patients (35.2 %) exhibited the "metabolic" phenotype, 17 patients (5.3 %) exhibited the "genetic" phenotype, 24 patients (7.4 %) exhibited the "biomechanical" phenotype, and 15 patients (4.6 %) exhibited the "post-traumatic" phenotype. The "osteoporotic" phenotype was significantly more frequent in patients aged 60 years or older (OR = 1.13 [1.10; 1.16], p < 0.0001) and in women (OR = 2.44 [1.20; 4.94], p < 0.0001). On the other hand, the "post-traumatic" phenotype was significantly more frequent in patients younger than 60 years (OR = 1.93 [1.91; 1.96], p < 0.0001) and in those with tibiofemoral osteoarthritis (OR = 0.44 [0.21; 0.94], p = 0.034). Conclusion: The osteoporotic and metabolic phenotypes were the most frequently observed. The osteoporotic phenotype was more common in women and patients over 60 years while the post-traumatic phenotype was more prevalent in tibiofemoral osteoarthritis under 60 years.
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