Evidence map›Paper›PMID 39991590›Full record

ArticleGlobal heart2025

Gender Disparity in Lipid Testing Among Over 0.5 Million Adults from Pakistan: Females are Tested Much Later Despite Higher LDL-Cholesterol Levels.

Amjad Nawaz, Madeeha Khan, Quratul Ain, Muhammad Amjad, Jaka Sikonja, Hijab Batool, Mohammad Iqbal Khan, Urh Groselj, Fouzia Sadiq

Abstract readMulticenter Study
In one paragraph

Article in Global heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amjad NawazShifa Tameer-e-Millat University, H-8/4, Islamabad 44000, Pakistan.ORCID 0000-0001-7431-9450
Madeeha KhanShifa Tameer-e-Millat University, H-8/4, Islamabad 44000, Pakistan.ORCID 0000-0002-3913-8539
Quratul AinShifa Tameer-e-Millat University, H-8/4, Islamabad 44000, Pakistan.ORCID 0000-0003-3727-338X
Muhammad AmjadJoint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0001-8191-635X
Jaka SikonjaDepartment of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Bohoriceva ulica 20, Ljubljana, Slovenia.ORCID 0000-0001-7843-8107
Hijab BatoolChemical Pathology, Chughtai Institute of Pathology, Lahore, Pakistan.ORCID 0000-0002-6155-9217
Mohammad Iqbal KhanDepartment of Vascular Surgery, Shifa Tameer-e-Millat University, Shifa International Hospital Islamabad, H-8/4, Islamabad 44000, Pakistan.ORCID 0009-0005-6270-1069
Urh GroseljDepartment of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Bohoriceva ulica 20, Ljubljana, Slovenia.ORCID 0000-0002-5246-9869
Fouzia SadiqShifa Tameer-e-Millat University, H-8/4, Islamabad 44000, Pakistan.ORCID 0000-0001-9399-6078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Dyslipidemia is the major risk factor for atherosclerotic cardiovascular disease (ASCVD); therefore, its early diagnosis and treatment is necessary. While previous studies in Pakistan focused on general lipid profiles, investigations into gender disparities in lipid testing remain scarce. Therefore, the present study aims to explore the gender disparity in lipid testing and lipid levels among the adult Pakistani population. Methods: The lipid profile data was obtained from a tertiary care hospital and a diagnostic laboratory with centers across Pakistan. Dyslipidemia was defined based on the criteria provided by the National Cholesterol Education Program (NCEP) guidelines. Gender-based differences in lipid levels were analysed by copula decomposition, breaking down dyslipidemia differences into composition and structure effects. Results: A total of 577,489 adults were included in this study. The highest number of tests (n = 86,709, 14.6%) were conducted in individuals aged between 50 to 54 years. Greater number of males (n = 203,415, 64.3%) were tested before the age of 50 years compared to females (n = 113,030, 35.7%). Conversely, after the age of 50 years, number of tests increased notably among females (n = 137,541, 52.7%) compared to males (n = 123,503, 47.3%; p < 0.001). For all comparisons, significant differences were observed for low density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) levels between males and females (p < 0.001), where average levels of LDL-C, TC and HDL-C were higher in females while average TG levels were higher in males. Conclusion: This study highlights the gender disparity in lipid testing in Pakistan, where females undergo lipid testing later in life, despite higher lipid levels compared to males.

Indexed as

Cholesterol, LDLDyslipidemiasLipidsAdultFemaleHumansMaleMiddle AgedPakistanRisk FactorsSex DistributionSex FactorsCholesterol, LDLLipidsCardiovascular diseaseDyslipidemiaGender DisparityLipid testingOpportunistic testingPakistan

Identifiers

PMID39991590
PMCPMC11844004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.