Evidence map›Paper›PMID 39991577›Full record

ArticleJournal of Cancer2025

NUPR1 contributes to endocrine therapy resistance by modulating BIRC5 expression and inducing luminal B-ERBB2

Chun-Hui Lee, Yi-Chen Lin, Yung-Chieh Chang, Pin-Chen Chen, Kai-Hsuan Lin, Tzu-Miao Yeh, Euphemia Yee Leung, I-Li Lin, Shang-Hung Chen, Chun Hei Antonio Cheung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chun-Hui LeeInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yi-Chen LinDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yung-Chieh ChangTMU Research Center of Cancer Translational Medicine and Taipei Cancer Center, Taipei Medical University Hospital, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Pin-Chen ChenDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kai-Hsuan LinInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tzu-Miao YehDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Euphemia Yee LeungAuckland Cancer Society Research Centre and Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
I-Li LinDepartment of Radiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
Shang-Hung ChenDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chun Hei Antonio CheungDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired resistance to endocrine therapy is a major clinical challenge in the treatment of luminal A [estrogen receptor (ER)

Indexed as

BIRC5Breast cancerdrug resistanceERBB2HDAC5NUPR1

Identifiers

PMID39991577
PMCPMC11843241

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.