Evidence map›Paper›PMID 39991542›Full record

ArticleiScience2025

Role of androgen receptors in sexually dimorphic phenotypes in UBE3A-dependent autism spectrum disorder.

Yuan Tian, Hui Qiao, KathrynAnn Odamah, Ling-Qiang Zhu, Heng-Ye Man

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Living with PCOS: A Narrative of its Biology, Diagnosis, and Evolving Treatment.Endocrine, metabolic & immune disorders drug targets · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yuan TianDepartment of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA.
Hui QiaoDepartment of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA.
KathrynAnn OdamahDepartment of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA.
Ling-Qiang ZhuDepartment of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Heng-Ye ManDepartment of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA.

Funding

Molecular Mechanisms of Homeostatic Synaptic PlasticityR01MH079407 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MAN, HENGYE · 2008 to 2018
$3.9M
Molecular mechanisms of homeostatic synaptic plasticityR01MH130600 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Hengye Man · 2023 to 2026
$1.9M
Study of NEXMIF mosaic expression on neuronal development and connectivity in female miceR21MH133014 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MAN, HENGYE · 2023 to 2024
$454k
Exploring the Rescue Strategy for Female NEXMIF Haploinsufficiency via X Chromosome ReactivationR21MH134174 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MAN, HENGYE · 2024 to 2024
$445k
NIMH NIH HHS R01 MH079407NIMH NIH HHS R01 MH130600NIMH NIH HHS R21 MH133014NIMH NIH HHS R21 MH134174
6 · The paper itself

Abstract

Autism spectrum disorders (ASDs) involve social, communication, and behavioral challenges. ASDs display a remarkable sex difference with a 4:1 male to female prevalence ratio; however, the underlying mechanism remains largely unknown. Using the UBE3A-overexpressing mouse model for ASD, we studied sexually dimorphic changes at behavioral, genetic, and molecular levels. We found that male mice with extra copies of

Indexed as

Human geneticsMolecular neuroscience

Identifiers

PMID39991542
PMCPMC11847089

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.