ArticleJournal of pain research2025
Effects of Xuefu Zhuyu Decoction on Inflammatory Factors and the NF-kappaB Signaling Pathway in Rats Model of Radicular Pain.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Randomized controlled trials of major oral traditional Chinese medicine preparations for postherpetic neuralgia: an evidence map.Frontiers in pharmacology · 2026Pooled it
- Acupuncture and Moxibustion Therapy Attenuates Inflammation in CCI-Induced Sciatica by Inhibiting the NF-κB Pathway.Journal of pharmacopuncture · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the therapeutic effects and mechanisms of Xuefu Zhuyu Decoction (XFZYD) on radicular pain in rats with lumbar disc herniation (LDH). Methods: Rat models of radicular pain were established and randomly divided into five groups: a control group, a model group, and three groups receiving low, medium, and high doses of XFZYD, with 12 rats per group. The rats in the treatment groups received different doses of XFZYD via oral administration, while the control and model groups received an equal volume of normal saline once daily for 7 days. Pain thresholds were measured, including the paw withdrawal threshold (PWT) and thermal paw withdrawal latency (PWL). The levels of inflammatory factors in the spinal dorsal horn tissue, including tumor necrosis factor α (TNF-α), transforming growth factor-β (TGF-β), interleukin-1β (IL-1β), and interleukin-6 (IL-6), were assessed using enzyme-linked immunosorbent assay (ELISA). Additionally, the expression of phosphorylated NF-κB in the spinal dorsal horn tissue was analyzed by Western blotting. Results: Compared to the control group, the PWT and PWL in the model group were significantly decreased ( Conclusion: Xuefu Zhuyu Decoction effectively reduces the release of inflammatory factors in the spinal dorsal horn of rats, enhances pain thresholds, and alleviates radicular neuropathic pain. The underlying mechanism may involve the inhibition of the NF-κB signaling pathway.
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