Evidence map›Paper›PMID 39991478›Full record

ArticleInnovation (Cambridge (Mass.))2025

Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting.

Zhijie Wang, Chutian Wang, Ying Ji, Mingxin Yang, Chan Li, Mengyao Li, Jingru Yang, Hongyu Tang, Xianwei Luo, Haoyang Hao and 7 more

Abstract read
In one paragraph

Article in Innovation (Cambridge (Mass.)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Review
  12. Review
  13. Micro/Nano-Motors for Enhanced Tumor Diagnosis and Therapy.International journal of molecular sciences · 2025
    Review
  14. Therapeutic applications of nanobots and nanocarriers in cancer treatment.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhijie WangKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Chutian WangSchool of Mechanical Engineering and Automation, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China.
Ying JiInstitute of Textiles and Clothing, School of Fashion and Textiles, Research Institute for Intelligent Wearable Systems, The Hong Kong Polytechnic University, Hong Kong SAR 999077, China.
Mingxin YangKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Chan LiSchool of Mechanical Engineering and Automation, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China.
Mengyao LiKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Jingru YangKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Hongyu TangKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Xianwei LuoKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Haoyang HaoKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhicai LiuKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Kui ChenKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Yanan ChangKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Hui YuanKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Lin FengSchool of Mechanical Engineering and Automation, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China.
Gengmei XingKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Juan LiKey Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed magnetically driven bionic drug-loaded nanorobots (MDNs) to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional (3D) magnetic manipulation platform (MMP) system to precisely control their movement mode. MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles (7.02 ± 0.18 nm). Doxorubicin (12% ± 2% [w/w]) was encapsulated in MDNs by an imide bond. MDNs could imitate the movement mode of a school of wild herrings (e.g., re-dispersion/arrangement/vortex/directional movement) to adapt to the changing and complex physiological environment through the 3D MMP system. MDNs overcame blood flow resistance and biological barriers using optimized magnetic driving properties according to

Indexed as

immunitymagnetic materialsnanorobotstargeted drug delivery

Identifiers

PMID39991478
PMCPMC11846086

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.