ArticleCureus2025
The Impact of Administering Human Plasma Protein Fraction 5% (PPF5%) in Major Liver Resection Surgeries.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction Albumin substantially influences the acid-base equilibrium within the human body and the regulation of acid-base homeostasis. The precise role of albumin remains a subject of debate. Human plasma protein fraction 5% (PPF5%) (Octapharma Pharmazeutika Produktionsgesellschaft m.b.H., Vienna, Austria) contains selected plasma with approximately 88% normal human albumin. We hypothesize that the use of PPF5% in patients undergoing liver resection surgery will enhance tissue perfusion and augment the buffering capacity of blood. Methods A prospective, randomized controlled study spanning 18 months was conducted at Hamad General Hospital, Qatar, involving 48 patients scheduled for liver resection surgeries. Patients were allocated into two groups: group A received an intravenous infusion of PPF5%, while group R received an intravenous infusion of crystalloid (lactated Ringer's solution). Acid-base electrolyte fluctuations were evaluated on four occasions at different time intervals. Results There were significant alterations within each group at different time points. Group A exhibited a substantial variance in strong ion difference (SID) values compared to group R at the time after liver resection (TAR) and at the time of end of surgery (TE). Group A demonstrated significantly enhanced tissue perfusion at TAR and TE relative to group R. There was a noteworthy decrease in hemoglobin and hematocrit levels in group A compared to group R at TE due to the hemodilution effect of the PPF5%. Conclusions The use of PPF5% in significant quantities for rehydration during liver resection procedures appears safe, exhibiting no equivalent alterations in acid-base balance, electrolyte levels, and coagulation when compared to lactated Ringer's solution. Moreover, it demonstrates improved tissue perfusion alongside increased hemodilution.
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