Evidence map›Paper›PMID 39991351›Full record

ArticleCureus2025

High-Dose Insulin Therapy for Refractory Shock in a Polypharmacy Overdose of Calcium Channel Blocker and Oral Hypoglycemic Agent: A Case Report and Literature Review.

Vinayak S R, Bipenthung N Jami, Austin J Mangaly, Krishnakumar R S, Gladson Vineeth, Chandni Radhakrishnan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vinayak S REmergency Medicine, Government Medical College, Kozhikode, Kozhikode, IND.
Bipenthung N JamiEmergency Medicine, Government Medical College, Kozhikode, Kozhikode, IND.
Austin J MangalyEmergency Medicine, Government Medical College, Kozhikode, Kozhikode, IND.
Krishnakumar R SEmergency Medicine, Government Medical College, Kozhikode, Kozhikode, IND.
Gladson VineethGeneral Medicine, Government Medical College, Kozhikode, Kozhikode, IND.
Chandni RadhakrishnanInternal Medicine, Government Medical College, Kozhikode, Kozhikode, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of polypharmacy overdose involving a calcium (Ca) channel blocker and an oral hypoglycemic agent, where conventional therapies failed to obtain the desired clinical outcome. High-dose insulin (HDI) therapy, a promising treatment regime in this regard, was carried out for our patient, and her condition improved over the subsequent days.

Indexed as

calcium channel blocker overdosedrug overdosehigh-dose insulin therapyrefractory shocksulfonylurea overdosetoxicology and envenomation

Identifiers

PMID39991351
PMCPMC11845794

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.