ArticleCureus2025
Drug-Induced Chylothorax During Chemotherapy With Ramucirumab and Paclitaxel for Advanced Gastric Cancer.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We encountered a rare case of ramucirumab (RAM)-induced chylothorax that resolved after treatment with a thoracic drain in a 75-year-old woman diagnosed with a HER2-positive advanced gastroduodenal carcinoma. Two weeks after initiating RAM and paclitaxel (PTX) treatment, a pleural fluid examination revealed chylothorax. Treatment with a thoracic drain was initially performed; however, continuous drainage was maintained even after the drain was placed. Since no leakage was observed on lymphoscintigraphy, she was treated without surgery or interventional radiology. The drainage volume gradually decreased; the patient was discharged after removing the thoracic drain. PTX alone was readministered, and chylothorax recurrence was not observed. We emphasized the possibility that RAM can cause chylothorax and that lymphoscintigraphy is useful for selecting treatment.
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