Evidence map›Paper›PMID 39991294›Full record

ArticleJTCVS techniques2025

Aortic leaflet remodeling for the repair of congenitally malformed aortic valve.

Hani K Najm, Lama Dakik, Batol Barodi, John P Costello, Munir Ahmad, Justin T Tretter

Abstract read
In one paragraph

Article in JTCVS techniques, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Early Favourable Outcomes of Valve Repair in Congenital Heart Surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hani K NajmDivision of Pediatric Cardiac Surgery, Department of Pediatrics, Pediatric Cardiology, Cleveland Clinic Children's, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Lama DakikDivision of Pediatric Cardiac Surgery, Department of Pediatrics, Pediatric Cardiology, Cleveland Clinic Children's, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Batol BarodiDivision of Pediatric Cardiac Surgery, Department of Pediatrics, Pediatric Cardiology, Cleveland Clinic Children's, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
John P CostelloDivision of Pediatric Cardiac Surgery, Department of Pediatrics, Pediatric Cardiology, Cleveland Clinic Children's, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Munir AhmadDivision of Pediatric Cardiac Surgery, Department of Pediatrics, Pediatric Cardiology, Cleveland Clinic Children's, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Justin T TretterDivision of Pediatric Cardiac Surgery, Department of Pediatrics, Pediatric Cardiology, Cleveland Clinic Children's, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Aortic valve repair techniques are still evolving with better understanding of aortic root and leaflet imaging. This study seeks to present the results of an additional new technique in aortic valve repair of patients with congenital heart disease. The technique entails remodeling of the leaflet by intentional peeling of the myxomatous tissue to remodel the thickened leaflets (from the ventricular side of the aortic valve along with thinning and plication of the central region of the leaflets). Other repair techniques are added to complete the repair. Methods: We performed a retrospective chart analysis of 19 patients who underwent aortic valve remodeling for aortic regurgitation and received advanced imaging preoperative assessment from January 2022 to February 2024. Institutional Review Board approval was obtained under expedited review for retrospective studies. Results: All patients with a wide range of congenital pathologies underwent leaflet remodeling; 9 patients (47%) underwent additional valve-sparing root replacement, and 6 patients (32%) received subaortic annuloplasty. Fifteen patients (79%) had moderate or severe aortic insufficiency at the time of presentation. Mean clinical follow-up was 10 months (range, 1.9-31). At follow-up, 7 patients did not have aortic regurgitation on echocardiogram, and the remaining 12 patients had mild regurgitation. None of the patients had more than mild regurgitation. All patients assessed for left ventricular ejection fraction at follow-up had an ejection fraction greater than 50%. None of the patients required reoperation. Conclusions: Leaflet remodeling by intentional peeling of myxomatous tissue expands leaflet dimensions by freeing tethered portions and improves mobility and coaptation. This additional technique will preserve more valves from replacement. However, further follow-up is needed.

Indexed as

aortic remodelingcongenital aortic valve pathologiesleaflet peeling

Identifiers

PMID39991294
PMCPMC11845394

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.