Evidence map›Paper›PMID 39991237›Full record

ArticleHeliyon2025

Clinical implications of proximal tubular multicilia in glomerular diseases.

Bohye Kim, Boram Weon, Evonne Kim, Sohee Park, Wencheng Jin, Nayeon Shin, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Lee, Obin Kwon and 1 more

Abstract read
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In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Bohye KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, South Korea.
Boram WeonDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.
Evonne KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, South Korea.
Sohee ParkDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, South Korea.
Wencheng JinDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.
Nayeon ShinDepartment of Internal Medicine, College of Medicine, Seoul National University, Seoul, South Korea.
Yun Kyu OhDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.
Chun Soo LimDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.
Jung Pyo LeeDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.
Obin KwonDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, South Korea.
Jeonghwan LeeDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Multiciliated cells (MCCs) have been identified in the proximal tubules of patients with kidney disease; however, their clinical significance is unknown. We aimed to investigate whether MCCs are associated with clinical outcomes in patients with glomerular diseases. Methods: Between August 2012 and April 2021, 134 patients (including 126 with glomerular disease patients and 8 controls) who were hospitalized at Seoul National University Boramae Medical Center and Seoul National University Hospital were included in this study. The ratio of MCCs to total proximal tubular cells was calculated using immunohistochemistry. The relationship between the MCC ratio and kidney disease-related clinical features was then analyzed. Results: MCCs were exclusively detected in patients with glomerular diseases (68.3 %), not those in the control group. Patients with diabetic kidney disease (88.9 %) or antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN, 86.4 %) had higher MCC ratios. MCC-positivity and MCC ratios were significantly associated with increased age and proteinuria, and a decreased estimated glomerular filtration rate (eGFR). Patients with higher MCC ratios had a significantly higher risk of end-stage kidney disease (ESKD) and composite outcomes with death. In multivariable analysis, MCC ratios were significantly correlated with an increased risk of ESKD (hazard ratio [HR], 1.413; 95 % confidence interval [CI], 1.012-1.972) and composite outcome (HR, 1.401; 95 % CI, 1.028-1.909). Conclusion: Higher MCC ratios were correlated with poorer prognosis; therefore, quantification of MCCs in the proximal tubules can serve as a valuable prognostic marker in clinical practice.

Indexed as

Diabetic kidney diseaseEnd-stage kidney diseaseEstimated glomerular filtration rateGlomerulonephritisMulticiliated cellsProteinuria

Identifiers

PMID39991237
PMCPMC11847256

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