Evidence map›Paper›PMID 39991196›Full record

ArticleGlomerular diseases

Genetic and Iatrogenic Defects in Peripheral Tolerance Associated with Anti-Nephrin Antibody-Associated Minimal Change Disease.

J Ashley Jefferson, Karin Chen, Sangeeta Hingorani, A Bilal Malik, Scott S Tykodi, Keith H Keller, Yuan Huang, Kelly D Smith, Robyn C Reed, Astrid Weins and 1 more

Abstract read
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In one paragraph

Article in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

J Ashley JeffersonDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.
Karin ChenDivision of Immunology, Department of Pediatrics, University of Washington, Seattle, WA, USA.
Sangeeta HingoraniDivision of Immunology, Department of Pediatrics, University of Washington, Seattle, WA, USA.
A Bilal MalikDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.
Scott S TykodiDivision of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.
Keith H KellerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yuan HuangRobert J. Tomsich Department of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH, USA.
Kelly D SmithDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Robyn C ReedDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Astrid WeinsDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Shreeram AkileshDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Minimal change disease (MCD) is a common cause of nephrotic syndrome in children and adults. Immune dysregulation is a contributor, but the relative roles of individual components of the immune system in MCD pathogenesis remain unclear. Case Presentation: Here, we present 2 patients with defects in immune tolerance mechanisms that developed MCD associated with anti-nephrin antibodies. The first patient had a pathogenic deletion in Conclusion: These cases demonstrate that genetic and iatrogenic mechanisms of breakdown in peripheral tolerance can lead to MCD.

Indexed as

Anti-nephrin antibodiesMinimal change diseaseNephrotic syndromePathologyPodocyte

Identifiers

PMID39991196
PMCPMC11845169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.