Evidence map›Paper›PMID 39991156›Full record

ArticleFrontiers in immunology2025

Single-cell RNA sequencing of circulating immune cells supports inhibition of

Ameth N Garrido, Rohan Machhar, Omar F Cruz-Correa, Darshini Ganatra, Sarah Q Crome, Joan Wither, Igor Jurisica, Dafna D Gladman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ameth N GarridoGladman-Krembil PsA Research Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Rohan MachharGladman-Krembil PsA Research Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Omar F Cruz-CorreaGladman-Krembil PsA Research Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Darshini GanatraGladman-Krembil PsA Research Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Sarah Q CromeAjmera Transplant Centre, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Joan WitherDepartment of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Igor JurisicaOsteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Dafna D GladmanGladman-Krembil PsA Research Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To identify biomarkers that distinguish psoriatic arthritis (PsA) from cutaneous psoriasis without arthritis (PsC) and healthy controls (HC) using single cell RNA sequencing (scRNA-seq). Method: Peripheral blood mononuclear cell samples from three patients with PsA fulfilling CASPAR criteria, three patients with PsC and two HC were profiled using scRNA-seq. Differentially expressed genes (DEGs) identified through scRNA-seq were validated on classical monocytes, and CD4 Results: A total of 18 immune cell population clusters were identified. Across 18 cell clusters, we identified 234 DEGs. Conclusion: These results suggest that translation of

Indexed as

Arthritis, PsoriaticNF-KappaB Inhibitor alphaTumor Necrosis Factor alpha-Induced Protein 3AdultBiomarkersCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansLeukocytes, MononuclearMaleMiddle AgedSequence Analysis, RNASingle-Cell AnalysisBiomarkersNF-KappaB Inhibitor alphaNFKBIA protein, humanTNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3NFKBIApsoriasispsoriatic arthritisscRNA-seqTNFAIP3

Identifiers

PMID39991156
PMCPMC11842318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.