Evidence map›Paper›PMID 39991118›Full record

ArticleApplied physics letters2025

3D protoacoustic radiography: A proof of principle study.

Prabodh K Pandey, Gilberto Gonzalez, Kristina Bjegovic, Leshan Sun, Yong Chen, Liangzhong Xiang

Abstract read
In one paragraph

Article in Applied physics letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Volumetric FLASH dosimetryPhysics in medicine and biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Prabodh K PandeyDepartment of Radiological Sciences, University of California, Irvine, California 92697, USA.ORCID https://orcid.org/0000-0002-8962-2580
Gilberto GonzalezDepartment of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.ORCID https://orcid.org/0009-0007-9805-8284
Kristina BjegovicDepartment of Biomedical Engineering, University of California, Irvine, California 92617, USA.
Leshan SunDepartment of Biomedical Engineering, University of California, Irvine, California 92617, USA.ORCID https://orcid.org/0009-0008-1312-2388
Yong ChenDepartment of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Academic-Industry Partnership for the Translation of a 4D in vivo Dosimetry Approach for Radiation TherapyR37CA240806 · NCI · UNIVERSITY OF OKLAHOMA · PI CHEN, YONG, IVANOV, VASSILI · 2019 to 2025
$2.9M
3D In vivo dosimetry for FLASH proton therapyU01CA288351 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yong Chen, Lei Ren · 2024 to 2026
$1.8M
Quantitative in vivo dosimetry for radiotherapy using model-based X-ray-induced acoustic computed tomographyR50CA283816 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Prabodh Kumar Pandey · 2024 to 2026
$317k
NCI NIH HHS P30 CA062203NCI NIH HHS R37 CA240806NCI NIH HHS R50 CA283816NCI NIH HHS U01 CA288351
6 · The paper itself

Abstract

We propose protoacoustic radiography (PAR), an imaging modality combining proton excitation and acoustic detection for three-dimensional (3D) imaging from a single proton projection. PAR avoids the effect of multiple Coulomb scattering in imaging by detecting ultrasound. Proton-induced acoustic waves propagate spherically, enabling 3D imaging from a single projection. Additionally, the distinctive feature of proton beams-concentrating energy deposition primarily at the Bragg peak-allows for precise depth-selectivity through proton energy tuning. We performed PAR using clinical proton machines, and our results demonstrate the capability of PAR to reconstruct targets at various depths (between ∼20 and 23 cm) with an axial resolution of 1.3 mm by fully leveraging the Bragg peak and by tuning the kinetic energy of the proton beam. PAR offers opportunities for precise structural determination with protons both in biomedicine and nondestructive testing.

Identifiers

PMID39991118
PMCPMC11842120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.