ReviewClinical and translational radiation oncology2025
Timeline of cognitive impairments after radiotherapy for head and neck cancer: A review.
Review in Clinical and translational radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term neurocognitive and behavioral outcomes in survivors of pediatric brain tumors: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Deep-learning-assisted brain contouring and serial neurocognitive monitoring in head and neck cancer survivorship: a prospective study.Clinical and translational radiation oncology · 2026Article
- Cancer-related cognitive impairment in adult cancer survivors: a clinical practice review for healthcare providers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Longitudinal changes in cognition, sleep, and psychological distress following the MORE program in head and neck cancer patients undergoing chemoradiotherapy.Scientific reports · 2026Article
- Radiation-induced eCIRP Causes Alzheimer's Disease-like Neuronal Tau Phosphorylation.Molecular neurobiology · 2026Article
- Importance of radiation-related cognitive decline in older adults who receive cranial radiation.Expert review of anticancer therapy · 2025Review
- Abscopal Brain Proteomic Changes Associated with Microbiome Alterations Induced by Gastrointestinal Acute Radiation Syndrome in Swine.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With advances in cancer treatments, long-term impairments of survivors have become more apparent. Radiotherapy of tumors in or near the brain can potentially induce cognitive impairments, impacting the quality of life of survivors. Currently, there is a lack of comprehensive information on the timeline of cognitive impairments following radiotherapy for head and neck cancer (HNC). To address this gap, we conducted a literature review on cognitive impairments observed after radiotherapy for HNC. Methods: The literature review was conducted using PubMed, Web of Science, PsycINFO, and Google Scholar. Search terms included the following keywords: head and neck tumors, radiotherapy, treatment responses, cognitive impairments, as well as variants and related subcategories. Result: Our review encompassed 23 studies involving a total of 1059 HNC patients, predominantly nasopharyngeal carcinoma. Overall, studies indicated a decline in cognitive performance post-radiotherapy compared to baseline scores, control groups, or normative data. The literature on acute effects is scarce and studies with complete neuropsychological assessments are missing. Cognitive impairments were prevalent in the majority of patients at six to 12 months post-radiotherapy, with memory deficits being the most prominent. Long-term assessments demonstrated that these cognitive deficits persisted even beyond seven years, suggesting a potentially irreversible decline in cognition following radiotherapy. Conclusion: Cognitive impairments are frequently observed at least six months after radiotherapy. Standardized cognitive assessments are imperative to evaluate impairments in individual patients. Future research in HNC should integrate neuropsychological evaluations to enhance our understanding of domain-specific impairments and the complete timeline of cognitive changes after radiotherapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.