Evidence map›Paper›PMID 39991090›Full record

ArticleDrug design, development and therapy2025

Comprehensive Bioactive Compound Profiling of

Lelly Yuniarti, Taufik Muhammad Fakih, Maya Tejasari, Raden Anita Indriyanti, Erni Maryam, Bambang Hernawan Nugroho

Abstract read
In one paragraph

Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Exploring the Anticancer Activity ofLife (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lelly YuniartiDepartment of Biochemistry, Faculty of Medicine, Universitas Islam Bandung, Jl. Tamansari, Bandung, 40116, Indonesia.ORCID 0000-0002-6329-1277
Taufik Muhammad FakihDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Jl. Ranggagading, Bandung, 40116, Indonesia.ORCID 0000-0001-7155-4412
Maya TejasariDepartment of Histology, Faculty of Medicine, Universitas Islam Bandung, Jl. Tamansari, Bandung, 40116, Indonesia.ORCID 0000-0001-8398-7397
Raden Anita IndriyantiDepartment of Pharmacology, Faculty of Medicine, Universitas Islam Bandung, Jl. Tamansari, Bandung, 40116, Indonesia.ORCID 0000-0001-5279-8032
Erni MaryamStudy Program in Skin Aging and Medical Aesthetics, Faculty of Medicine, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, 40531, Indonesia.
Bambang Hernawan NugrohoDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Jl. Kaliurang, Sleman, 55584, Indonesia.ORCID 0000-0002-2862-4857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Patients and Methods: Ethanol and ethyl acetate extracts were analyzed using Thin Layer Chromatography (TLC) and Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS). Antioxidant activity was determined via DPPH radical scavenging and tyrosinase inhibition was compared against kojic acid. Molecular docking and molecular dynamics simulations explored binding interactions of Artocarpin and Sitosterol with matrix metalloproteinases (MMPs) and tyrosinase. Results: Artocarpin and Sitosterol were identified as primary bioactive compounds. Ethanol extracts exhibited stronger tyrosinase inhibition (IC Conclusion: Artocarpin and Sitosterol from

Indexed as

AntioxidantsArtocarpusEnzyme InhibitorsPhytochemicalsPlant ExtractsPlant LeavesBiphenyl CompoundsChromatography, LiquidDose-Response Relationship, DrugHumansLiquid Chromatography-Mass SpectrometryMannose-Binding LectinsMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureMonophenol Monooxygenase1,1-diphenyl-2-picrylhydrazylAntioxidantsartocarpin lectinBiphenyl CompoundsEnzyme Inhibitorsgamma-sitosterolMannose-Binding LectinsMonophenol MonooxygenasePhytochemicalsPicratesPlant ExtractsPlant LectinsSitosterolsantioxidant activityArtocarpus heterophyllusbioactive compound profilingcomputational studytyrosinase inhibition

Identifiers

PMID39991090
PMCPMC11846532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.