Evidence map›Paper›PMID 39991001›Full record

ArticleBiomedical reports2025

Scutellarein enhances cisplatin‑induced apoptotic effects by suppressing the PI3K/AKT‑MDR1 pathway in human NPC/HK1 nasopharyngeal carcinoma cells.

Yen-Ting Wu, Lei-Chin Chen, Han-Hsuan Wang, Chen-Xuan He, Chia-Hung Chien, Chih-Chieh Tao, Yingxiao Li, Yun-Ju Chen, Yu-Yan Lan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yen-Ting WuDepartment of Pathology, Golden Hospital, Pingtung 90049, Taiwan, R.O.C.
Lei-Chin ChenDepartment of Nutrition, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan, R.O.C.
Han-Hsuan WangDepartment of Medical Laboratory Science, College of Medical Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan, R.O.C.
Chen-Xuan HeDepartment of Medical Imaging and Radiological Sciences, College of Medical Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan, R.O.C.
Chia-Hung ChienSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan, R.O.C.
Chih-Chieh TaoSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan, R.O.C.
Yingxiao LiSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan, R.O.C.
Yun-Ju ChenDepartment of Pharmacy, E-Da Hospital, Kaohsiung 82445, Taiwan, R.O.C.
Yu-Yan LanSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of radiotherapy and chemotherapy has significantly improved survival rates for patients with nasopharyngeal carcinoma (NPC). Nonetheless, some patients still experience poor outcomes, potentially due to resistance to cisplatin, a widely used chemotherapeutic agent. Scutellarein, a compound extracted from

Indexed as

apoptosiscisplatinnasopharyngeal carcinoma cellsscutellareinviability

Identifiers

PMID39991001
PMCPMC11843199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.