ArticleACS bio & med chem Au2025
NIR-Responsive Black Phosphorus Nanosheet-Integrated Niosomes for Combinatorial Chemo-phototherapy of Cancers.
Article in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Harnessing the Power of Nanocarriers to Exploit the Tumor Microenvironment for Enhanced Cancer Therapy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Recent advancements and perspectives of photoresponsive inorganic nanomaterials for cancer phototherapy and diagnosis.RSC advances · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer remains one of the major challenges in the field of clinical biomedicine. There is a great deal of scope for the development of various innovative therapies. To advance in the field of cancer therapeutics, the research trend has gradually shifted to the development of biocompatible, controlled, and stable carrier systems. To address such issues, herein, we report NIR-responsive black phosphorus (BP) nanosheet-integrated niosomes to mediate chemo-phototherapy of cancers. Niosome-coated black phosphorus nanosheets loaded with indocyanine green (ICG) and doxorubicin (DOX) (NBID) exhibit very high drug loading efficiency (>90%). Upon 808 nm NIR light irradiation, the NBID system initiates combinatorial effects where heat generation induced from BP nanosheets and ICG disrupts the niosomal coating, facilitating the controlled release of ICG and DOX in a pH- and light dual-responsive manner. This combinatorial approach induces DNA damage in cancer cells via DOX and also triggers photothermal (PTT) and photodynamic (PDT) effects, significantly enhancing tumor eradication. In a 2D cell culture model, the NBID formulation demonstrates excellent cytocompatibility in the dark, effective tumor cell uptake, and tumor cell death, showing potential for further application. To mimic the cancer microenvironment even more closely, the NBID nanoformulation has been tested against the 3D tumor spheroids, where NBID formulation shows tumor uptake and causes cancer cell death. The therapeutic efficacy of the NBID system can be controlled by laser, proving its light-responsive behavior to kill cancer cells in vitro. This integrated approach using NBID as a potent platform for combinatorial cancer therapy offers a promising advancement in achieving a safer, controlled, and stable drug delivery system.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.