Evidence map›Paper›PMID 39990941›Full record

ArticleACS bio & med chem Au2025

Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M

Jessica R Kenneson, Christina Papini, Su Tang, Kathy Huynh, Chun-Hui Zhang, William L Jorgensen, Karen S Anderson

Abstract read
In one paragraph

Article in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica R KennesonDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.
Christina PapiniDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.
Su TangDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.ORCID https://orcid.org/0000-0002-6993-1212
Kathy HuynhDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.
Chun-Hui ZhangDepartment of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.
William L JorgensenDepartment of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.ORCID https://orcid.org/0000-0002-3993-9520
Karen S AndersonDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.ORCID https://orcid.org/0000-0003-3433-0780

Funding

Targeting druggable coronavirus proteinsU19AI171443 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Juan C. de la Torre · 2022 to 2026
$101.4M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
POTENTIAL FUNCTIONS FOR WATER PROTEIN INTERACTIONSR01GM032136 · NIGMS · YALE UNIVERSITY · PI JORGENSEN, WILLIAM L. · 1985 to 2023
$8.2M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
NIAID NIH HHS U19 AI171443NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM032136NIH HHS S10 OD021527
6 · The paper itself

Abstract

SARS-CoV-2 M

Identifiers

PMID39990941
PMCPMC11843330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.