Interventions to Reduce Risk in the Physiologically Difficult Pediatric Airway: A Descriptive Study and Exploratory Analysis.

Objectives: Patients with physiologically difficult airways are at high risk for peri-intubation cardiac arrest in the pediatric emergency department (PED). We sought to describe how preintubation interventions designed to improve physiologic status are used and if they are associated with a reduction in peri-intubation cardiac arrest. Methods: We completed a secondary analysis of a multicenter, retrospective cohort of patients <21 years old requiring tracheal intubation in 8 academic PEDs. Included patients underwent rapid sequence intubation and met at least 1 of 6 criteria for a physiologically difficult airway. We examined administration rates of preintubation interventions (intravenous [IV] fluids, vasoactive medications, and sodium bicarbonate) overall and by high-risk criteria. In an exploratory analysis, we assessed the relationship of preintubation interventions with peri-intubation cardiac arrest using weighted propensity scores and generalized linear mixed models. Results: Of 332 included patients, 264 patients (80%) received at least 1 intervention. A total of 257 (77%) patients received IV fluids, 87 (26%) received vasoactive medications, and 20 (6%) received sodium bicarbonate. Across sites, there were wide ranges of administration of IV fluids (59%-98%), vasoactive medications (10%-58%), and sodium bicarbonate (0%-36%). Preintubation interventions were not associated with peri-intubation cardiac arrest (odds ratio, 1.59; 95% CI 0.50 to 5.05). Conclusion: In PED patients with physiologically difficult airways, there is wide variability in the use of preintubation interventions. Receiving preintubation interventions was not associated with peri-intubation cardiac arrest. Future video-based prospective studies are needed to further evaluate interventions designed to prevent peri-intubation cardiac arrest.