Evidence map›Paper›PMID 39990916›Full record

ArticleKidney international reports2025

A Targeted Release Capsule of Lanthanum Carbonate: a New Efficient Cheap Treatment for Primary Hyperoxalurias.

Marc E De Broe, Marc P Uytterhoeven, Jan De Causmaecker, Yannick De Brucker, Erik D Snelders, Johan Van De Walle, Koen Van Hoeck, Dominique Trouet, Monique Elseviers

Erratum issuedAbstract read
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Hyperoxaluria: Diagnosis and Treatment.The Urologic clinics of North America · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Marc E De BroeLaboratory of Pathophysiology, University of Antwerp, Wilrijk, Belgium.
Marc P UytterhoevenSonic Healthcare Benelux AML, Antwerp, Belgium.
Jan De CausmaeckerPharmacist, Lokeren, Belgium.
Yannick De BruckerDepartment of Radiology, Vrije Universiteit Brussels, Ixelles, Belgium.
Erik D SneldersDepartment of Nephrology, Antwerp University Hospital, Edegem, Belgium.
Johan Van De WalleDepartment Pediatric Nephrology, Ghent University Hospital, Ghent, Belgium.
Koen Van HoeckLaboratory of Experimental Medicine and Pediatrics (LEMP), University of Antwerp, Wilrijk, Belgium.
Dominique TrouetLaboratory of Experimental Medicine and Pediatrics (LEMP), University of Antwerp, Wilrijk, Belgium.
Monique ElseviersCenter for Research and Innovation in Care, University of Antwerp, Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Primary hyperoxaluria (PH) is a devastating disease in children and adults. Recently, a substantial progress in the treatment of this deadly disease has been made that consists of the introduction of the RNA inhibitors, lumasiran and nedosiran, which deplete the substrate for oxalate synthesis. Methods: Lanthanum carbonate (Lanth.Carb., La Results: Four patients with PH and estimated glomerular filtration rate > 60 ml/min per 1.73 m Conclusion: trcLanth.Carb. is a promising repurposed, efficient, nontoxic, and cheap drug, lacking serious side effects in the treatment of any type of PH in whatever place in the world. A randomized controlled trial supporting this proof-of-concept is the next step.

Indexed as

cheapefficientprimary hyperoxaluriastrc-Lanthanum Carbonatetreatment

Identifiers

PMID39990916
PMCPMC11843112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.