ArticleKidney international reports2025
CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology.
Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Research Progress on the Pathogenesis and Diagnostic and Therapeutic Potential of Ciliopathies Regulated by IFT172.Clinical genetics · 2026Review
- Kidney disease and surveillance testing in children with Bardet-Biedl syndrome: an administrative data study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Clinical heterogeneity associated with Bardet-Biedl syndrome-related genes in presumed non-syndromic inherited retinal disease.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
13 authors.
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Abstract
Introduction: Chronic kidney disease (CKD) is a critical prognostic factor in Bardet-Biedl syndrome (BBS). Early diagnosis and intervention are essential for improving patient outcomes. The present study analyzed kidney function in patients with BBS, with the aim to explore the impact of genetic variants and common risk factors for kidney disease. Methods: A monocentric cross-sectional study was conducted. Patients underwent genetic analysis via next generation sequencing; renal function was assessed and the relationship with the following: (i) age, obesity, hypertension and (ii) genetic mutations was analyzed. Results: A total of 65 patients with BBS were enrolled in the study; renal function was variable, with 25% of patients showing an estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m Conclusion: The present study suggests that BBS is a condition of vulnerability to develop kidney disease, and that age, hypertension and obesity are associated with eGFR decline in adult patients with BBS. Whether effective interventions to treat modifiable factors will reduce CKD risk requires further studies.
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