ArticleKidney international reports2025
The Brophy Kit: A Manual Hemodialysis Device for Neonates.
Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparison of Kirpa Kit™ manual hemodialysis device to standard continuous kidney replacement therapy in vitro.Pediatric nephrology (Berlin, Germany) · 2026Article
- Renal replacement therapy in the neonatal intensive care unit: balancing neonatal expertise with practicality - Proceedings from the First International Neonatal Nephrology Symposium.Pediatric research · 2026Article
- In vitro measurements of ultrafiltration precision in hemofiltration and hemodialysis devices used in infants, Part 2: Comparison of PrisMax and CARPEDIEM with previous data on NIDUS, Prismaflex and Aquarius.Pediatric nephrology (Berlin, Germany) · 2025Article
- Response to "The Urgent Need for Hemodialysis and Ultrafiltration Devices Specifically Designed for Neonates".Kidney international reports · 2025Article
- The Urgent Need for Hemodialysis and Ultrafiltration Devices Specifically Designed for Neonates.Kidney international reports · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
Introduction: Acute kidney injury (AKI) is common in critically ill neonates, including very and extremely low birth weight (VLBW, ELBW) neonates. In severe cases, kidney replacement therapy (KRT) may be warranted. Currently, available KRT devices are only indicated for those weighing ≥ 2.5 kg and require a double lumen or 2 separate single lumen catheters. We miniaturized the Kirpa Kit manual dialysis device, naming it the Brophy Kit, and we assessed its Methods: We diluted packed red blood cells to a normal hematocrit (Hct: 31.1%-36.8%) and conducted 12 clearance and 3 UF experiments. A cycle consisted of aspirating 10 ml of blood from the blood bag, passing it through a hemofilter, and returning it in a circular path. For clearance experiments, we tested 4 configurations, with varied timing and volume of saline flushes to refresh the dialysis compartment, then measured blood urea nitrogen (BUN) and potassium concentrations every 5 cycles. For each UF cycle, 1 ml of ultrafiltrate was removed, and Hct was measured every 10 cycles. Results: Median BUN and potassium reduction were 31.0% (interquartile range [IQR]: 17.6-37.9) and 35.0% (IQR: 26.9-41.7), respectively, after 30 clearance cycles. Median Hct increased to 52.6% (IQR: 52.5-53.8) after 60 UF cycles, more than the expected Hct (47.7%). Conclusion: The Brophy Kit performs
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