Evidence map›Paper›PMID 39990877›Full record

ArticleKidney international reports2025

Association Between Albuminuria and Glomerular Filtration Rate With Incident Frailty.

Elisa K Bongetti, Anna L Wilkinson, James B Wetmore, Anne M Murray, Robyn L Woods, Sara Espinoza, Michael E Ernst, Michelle A Fravel, Suzanne G Orchard, Le Thi Phuong Thao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisa K BongettiDepartment of Nephrology, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.
Anna L WilkinsonSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
James B WetmoreDivision of Nephrology, Hennepin Healthcare, Minneapolis, Minnesota, USA.
Anne M MurrayBerman Center for Outcomes and Clinical Research and Department of Medicine, Hennepin Healthcare Research Institute, and Department of Medicine, Geriatrics Division, Hennepin Healthcare Minneapolis, Minnesota, USA.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Sara EspinozaCenter for Translational Geroscience, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Michael E ErnstDepartment of Pharmacy Practice and Science, College of Pharmacy; and, Department of Family Medicine, Carver College of Medicine. The University of Iowa, Iowa City, Iowa, USA.
Michelle A FravelDepartment of Pharmacy Practice and Science, College of Pharmacy; and, Department of Family Medicine, Carver College of Medicine. The University of Iowa, Iowa City, Iowa, USA.
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Le Thi Phuong ThaoSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Kevan R PolkinghorneDepartment of Nephrology, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
NIA NIH HHS U01 AG029824
6 · The paper itself

Abstract

Introduction: The association between estimated glomerular filtration rate (eGFR) and albuminuria with incident frailty in generally healthy older individuals is unclear. We investigated whether baseline eGFR or urine albumin-to-creatinine ratio (UACR) are associated with incident frailty and assessed them using 2 separate methods: a modified Fried frailty phenotype (FP), and a deficit accumulation frailty index (FI). Methods: This was a secondary analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) randomized trial cohort, which enrolled independent, healthy, older adults aged ≥65 years in Australia and the USA. Time to incident frailty was analyzed using discrete time survival analysis. Results: In total, 16,965 participants were included using the FP, mean age was 75.0 ± 4.5 years, median baseline eGFR was 78.6 ml/min per 1.73 m Conclusion: In older, generally healthy adults, both low and high eGFRs were associated with increased risk of incident frailty. Doubling of UACR, even at low levels, was independently associated with incident frailty.

Indexed as

albuminuriachronic kidney diseaseelderlyfrailtykidney function testsolder adult

Identifiers

PMID39990877
PMCPMC11843128

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.