[Causal Relationship Between Components of Metabolic Syndrome and Endometrial Carcinoma].

Objective: To investigate the causal associations between components of metabolic syndrome (MetS) and endometrial carcinoma using Mendelian randomization (MR). Methods: Data mining of the Genome-Wide Association Studies (GWAS) database was performed, with the exposure factors being MetS components (lipids, blood pressure, blood glucose, and obesity) and the outcome factor being endometrial carcinoma. MR analyses were performed with the help of regression models, including MR-Egger method, weighted median method, and inverse variance weighted (IVW) method, and the causal relationship between MetS components and endometrial carcinoma was evaluated by odds ratio (OR). Reverse MR analysis was performed for the MetS components found to have a causal relationship with endometrial carcinoma in the forward MR analysis. Results: After applying Benjamini-Hochberg correction, IVW results showed a causal relationship between multiple MetS components (obesity, lipids, blood pressure, and blood glucose) and endometrial carcinoma. Specifically, the three components of obesity, including body mass index, overweight, and percentage of body fat, were causally associated with an increased risk of endometrial carcinoma ( Conclusion: The MR study suggests that obesity and type 2 diabetes mellitus are risk factors for endometrial carcinoma, while other MetS components, including hyperlipidemia, cardiovascular diseases, insulin resistance, and complications of diabetes mellitus, are protective factors for endometrial carcinoma. Further research is needed to clarify the association between MetS and endometrial carcinoma and to further explore the underlying mechanisms involved.