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Objective: To investigate the protective effect of Methods: After undergoing physiological synchronization, 30 female Wistar rats were randomly and evenly assigned to 3 groups, including a plain control (C) group, a high-altitude hypoxia (H) group, and a high-altitude hypoxia + LBP (H-LBP) group. The C group was placed in a region at an altitude of 1500 m above sea level (with an oxygen volume fraction of 18.55%), while the H group and the H-LBP group were placed in a region at an altitude of 4010 m above sea level (with an oxygen volume fraction of 12.70%). Rats in the H-LBP group were fed with LBP at 75 mg/kg via gastric gavage, while the C and H groups received normal saline once a day for 14 days in a row. Changes in estrous cycles were documented throughout the experiment. At the end of the experiment, the serum levels of reproductive hormones and the levels of oxidative stress in the ovarian and uterine tissues were measured. Morphological changes in the ovarian and uterine tissues were assessed using hematoxylin-eosin (HE) staining. A component-target-pathway network diagram was constructed using network pharmacology methods to analyze the key targets and pathways. Results: Compared with the C group, rats in the H group had disrupted estrous cycles and significantly lower serum levels of reproductive hormones (all Conclusion: LBP can ameliorate high-altitude hypoxia-induced reproductive damage in female rats. The mechanisms involved may be associated with the regulation of PI3K-Akt, MAPK, and HIF-1 pathways.