ReviewSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2024
[Latest Findings on the Role of Liquid-Liquid Phase Separation in the Regulation of Immune Cell Activation and Key Signaling].
Review in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Targeting phase separation: a new strategy to disrupt the stromal-immune axis in colorectal cancer.Cell communication and signaling : CCS · 2026Review
- [Nuclear Factor I-X Regulates Molecular Pathways Related to Craniofacial Development Through Phase Separation].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liquid-liquid phase separation (LLPS) is a process in which certain proteins or protein-RNA complexes form phase-separated droplets with different components and properties through multivalent interactions within a cell. In recent years, the role of LLPS in immunomodulation has received extensive attention. Compared with phase separation-related studies in other fields, limited research has been done on LLPS and the immune system. In this review, we first introduced the basic characteristics of LLPS associated with the immune system, and then explored the functions of LLPS in innate immune-related signaling pathways and adaptive immune cells. LLPS plays a crucial role in immune signal transduction, immune cell activation, and antigen presentation. It is involved in facilitating the aggregation of signaling molecules, regulating the intensity and duration of signal transduction, and influencing the functional state of immune cells. The discovery of LLPS provides a new theoretical basis for elucidating the activation mechanism of the immune system and is expected to bring new perspectives for understanding the cellular defense mechanisms. In-depth investigation of the role of LLPS in the immune system not only helps us gain a more comprehensive understanding of the immune response process, but also provides potential targets and strategies for the development of new immunotherapies and the treatment of autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.